Observational studyDiabetologia2017
Exposure to severe famine in the prenatal or postnatal period and the development of diabetes in adulthood: an observational study.
Observational study in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early-Life Exposure to the Chinese Famine of 1959-1961 and Type 2 Diabetes in Adulthood: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Severe malnutrition or famine exposure in childhood and cardiometabolic non-communicable disease later in life: a systematic review.BMJ global health · 2021Pooled it
- Glycation and receptors: coming of AGE in the midst of danger.Nature reviews. Endocrinology · 2026Review
- Epigenetic legacy of early-life undernutrition: methodological lessons from Dutch and Chinese famine studies.Frontiers in genetics · 2026Review
- Prenatal exposure to genocide accelerates epigenetic aging in third- and fourth-generation clocks among young adults in Rwanda.Communications medicine · 2025Article
- Early-life famine exposure, genetic susceptibility and risk of MAFLD in adulthood.The journal of nutrition, health & aging · 2025Article
- Fetal exposure to famine increases the risk of cardiovascular disease in adulthood: findings from a population-based screening study.Frontiers in cardiovascular medicine · 2025Article
- Article
- Re-examining the reversal hypothesis: A nationwide population-based study of the association between socioeconomic status, and NCDs and risk factors in China.SSM - population health · 2023Article
- Effects of Nutritional and Social Factors on Favorable Fetal Growth Conditions Using Structural Equation Modeling.Nutrients · 2022Article
- Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming.Cell discovery · 2022Article
- Impact of prenatal famine exposure on adulthood fasting blood glucose level.Scientific reports · 2022Article
- Metabolites in the association between early-life famine exposure and type 2 diabetes in adulthood over a 5-year follow-up period.BMJ open diabetes research & care · 2021Article
- Consequences of exposure to prenatal famine on estimated glomerular filtration rate and risk of chronic kidney disease among survivors of the great Ethiopian famine (1983-85): a historical cohort study.Nutrition journal · 2021Article
- The Glucagon-Like Adipokinetic Hormone inFrontiers in physiology · 2021Review
- Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study.Frontiers in cardiovascular medicine · 2021Article
- Combined Effect of Famine Exposure and Obesity Parameters on Hypertension in the Midaged and Older Adult: A Population-Based Cross-Sectional Study.BioMed research international · 2021Article
- AKH Signaling inFrontiers in physiology · 2021Article
- Ten SNPs May Affect Type 2 Diabetes Risk in Interaction with Prenatal Exposure to Chinese Famine.Nutrients · 2020Article
- Childhood severe acute malnutrition is associated with metabolomic changes in adulthood.JCI insight · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisLimited studies have compared the effect of prenatal or postnatal exposure to different severities of famine on the risk of developing diabetes. We aimed to measure the association between diabetes in adulthood and the exposure to different degrees of famine early in life (during the prenatal or postnatal period) during China's Great Famine (1959-1962).
methodsData from 3967 individuals were included (a total of 2115 individuals from areas severely affected by famine, 1858 from moderately affected areas, 6 excluded due to missing data). A total of 2335 famine-exposed individuals were further divided into those exposed during the fetal stage, childhood or adolescence/young adulthood. We constructed a difference-in-differences model to compare HbA
resultsIndividuals who had been exposed to famine during the fetal period, childhood, and adolescence/adulthood and who had lived in a severely affected area had a 0.31%, 0.20% and 0.27% higher HbA CONCLUSIONS/
interpretationExposure to severe famine in the fetal or childhood period may predict a higher HbA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.