Evidence map›Paper›PMID 27807421›Full record

ArticleFrontiers in physiology2016

Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways.

Rafael Barreto, Giorgia Mandili, Frank A Witzmann, Francesco Novelli, Teresa A Zimmers, Andrea Bonetto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.

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  18. GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Rafael BarretoDepartment of Surgery, Indiana University School of Medicine Indianapolis, IN, USA.
Giorgia MandiliCentre for Experimental and Clinical Studies, University of TorinoTorino, Italy; Department of Molecular Biotechnology and Health Sciences, University of TorinoTorino, Italy.
Frank A WitzmannDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine Indianapolis, IN, USA.
Francesco NovelliCentre for Experimental and Clinical Studies, University of TorinoTorino, Italy; Department of Molecular Biotechnology and Health Sciences, University of TorinoTorino, Italy.
Teresa A ZimmersDepartment of Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Simon Cancer Center, Indiana University School of MedicineIndianapolis, IN, USA; Center for Cachexia Research Innovation and Therapy, Indiana University - Purdue University IndianapolisIndianapolis, IN, USA.
Andrea BonettoDepartment of Surgery, Indiana University School of MedicineIndianapolis, IN, USA; Simon Cancer Center, Indiana University School of MedicineIndianapolis, IN, USA; Center for Cachexia Research Innovation and Therapy, Indiana University - Purdue University IndianapolisIndianapolis, IN, USA; Department of Otolaryngology, Head and Neck Surgery, Indiana University School of MedicineIndianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USUniversity of Turin · ITIndiana University Health · USIndiana University School of Medicine

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Manipulation of STAT3 Signaling for Muscle Preservation in Cancer CachexiaR01CA122596 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZIMMERS, TERESA A · 2010 to 2015
$1.6M
PQB3: Mechanisms & Targeting of Sonic Hedgehog Signaling in Muscle Wasting of Cancer CachexiaR01CA194593 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI ZIMMERS, TERESA A · 2015 to 2018
$1.4M
(PQB-3) Roles of skeletal muscle mass in chemotherapy-associated cachexiaR21CA190028 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI BONETTO, ANDREA · 2014 to 2015
$373k
NCATS NIH HHS UL1 TR001108NCI NIH HHS R01 CA122596NCI NIH HHS R01 CA194593NCI NIH HHS R21 CA190028
6 · The paper itself

Abstract

Cachexia represents one of the primary complications of colorectal cancer due to its effects on depletion of muscle and fat. Evidence suggests that chemotherapeutic regimens, such as Folfiri, contribute to cachexia-related symptoms. The purpose of the present study was to investigate the cachexia signature in different conditions associated with severe muscle wasting, namely Colon-26 (C26) and Folfiri-associated cachexia. Using a quantitative LC-MS/MS approach, we identified significant changes in 386 proteins in the quadriceps muscle of Folfiri-treated mice, and 269 proteins differentially expressed in the C26 hosts (

Indexed as

C26cachexiaFolfiriinflammationmitochondriamitochondrial fusion and fissionmuscleproteomics

Identifiers

PMID27807421
PMCPMC5070123
OpenAlexW2534399581

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.