Evidence map›Paper›PMID 27807377›Full record

Trial reportThe Canadian veterinary journal = La revue veterinaire canadienne2016

Fixed-dose-rate administration of gemcitabine in cancer-bearing cats: A pilot study.

Crystal L Garnett, Teri A Guerrero, Carlos O Rodriguez

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC
In one paragraph

Trial report in The Canadian veterinary journal = La revue veterinaire canadienne, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Crystal L GarnettWilliam R. Pritchard Veterinary Medical Teaching Hospital (Garnett, Guerrero, Rodriguez) and Department of Veterinary Surgical and Radiological Sciences (Rodriguez), University of California, Davis, USA.
Teri A GuerreroWilliam R. Pritchard Veterinary Medical Teaching Hospital (Garnett, Guerrero, Rodriguez) and Department of Veterinary Surgical and Radiological Sciences (Rodriguez), University of California, Davis, USA.
Carlos O RodriguezWilliam R. Pritchard Veterinary Medical Teaching Hospital (Garnett, Guerrero, Rodriguez) and Department of Veterinary Surgical and Radiological Sciences (Rodriguez), University of California, Davis, USA.
Veterinary Medical Teaching Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gemcitabine is an antimetabolite chemotherapy agent with schedule-dependent metabolism and efficacy. The purpose of this study was to identify the fixed-dose-rate (FDR) of gemcitabine administration in cancer-bearing cats that achieved a target plasma concentration (TPC) of 10 to 20 μM. Fifteen client-owned cats received gemcitabine infusions administered at various FDR for 1 to 6 hours. Plasma gemcitabine and dFdU (2',2'-difluorodeoxyuridine), the major gemcitabine metabolite, were quantitated by high performance liquid chromatography. Cats treated with an FDR less than 2.5 mg/m

Indexed as

AnimalsAntimetabolites, AntineoplasticCarcinomaCat DiseasesCatsDeoxycytidineDose-Response Relationship, DrugFemaleGemcitabineMalePilot ProjectsSarcomaAntimetabolites, AntineoplasticDeoxycytidineGemcitabine

Identifiers

PMID27807377
PMCPMC5081144
OpenAlexW2558328475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.