Trial reportNature communications2016
Induced sensorimotor brain plasticity controls pain in phantom limb patients.
Trial report in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 78 citations in OpenAlex.
- Neurofeedback modulation of insula activity via MEG-based brain-machine interface: a double-blind randomized controlled crossover trial.Communications biology · 2025Trial
- BCI training to move a virtual hand reduces phantom limb pain: A randomized crossover trial.Neurology · 2020Trial
- MEG-BMI to Control Phantom Limb Pain.Neurologia medico-chirurgica · 2018Trial
- The effects of physical exercise on inflammation-induced maladaptive neuroplasticity in post-traumatic headache.Neuroscience · 2026Review
- EEG-based brain-computer interface with immersive virtual reality for phantom limb pain: a single-center pilot neurofeedback trial.Frontiers in human neuroscience · 2026Article
- Neural interfaces: Bridging the brain to the world beyond healthcare.Exploration (Beijing, China) · 2024Article
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Is Phantom Limb Awareness Necessary for the Treatment of Phantom Limb Pain?Neurologia medico-chirurgica · 2024Review
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study.Scientific reports · 2024Article
- Fractal Similarity of Pain Brain Networks.Advances in neurobiology · 2024Article
- A Hidden Markov Model reveals magnetoencephalography spectral frequency-specific abnormalities of brain state power and phase-coupling in neuropathic pain.Communications biology · 2022Article
- Focusing on cognitive potential as the bright side of mental atypicality.Communications biology · 2022Review
- Unveiling the phantom: What neuroimaging has taught us about phantom limb pain.Brain and behavior · 2022Review
- Cortical plasticity and nerve regeneration after peripheral nerve injury.Neural regeneration research · 2021Article
- Surgical prevention of terminal neuroma and phantom limb pain: a literature review.Archives of plastic surgery · 2021Article
- Typical somatomotor physiology of the hand is preserved in a patient with an amputated arm: An ECoG case study.NeuroImage. Clinical · 2021Article
- Interaction in Assistive Robotics: A Radical Constructivist Design Framework.Frontiers in neurorobotics · 2021Article
- Review
- Microglia: sculptors of neuropathic pain?Royal Society open science · 2020Review
- Role of Potassium Ions Quantum Tunneling in the Pathophysiology of Phantom Limb Pain.Brain sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cause of pain in a phantom limb after partial or complete deafferentation is an important problem. A popular but increasingly controversial theory is that it results from maladaptive reorganization of the sensorimotor cortex, suggesting that experimental induction of further reorganization should affect the pain, especially if it results in functional restoration. Here we use a brain-machine interface (BMI) based on real-time magnetoencephalography signals to reconstruct affected hand movements with a robotic hand. BMI training induces significant plasticity in the sensorimotor cortex, manifested as improved discriminability of movement information and enhanced prosthetic control. Contrary to our expectation that functional restoration would reduce pain, the BMI training with the phantom hand intensifies the pain. In contrast, BMI training designed to dissociate the prosthetic and phantom hands actually reduces pain. These results reveal a functional relevance between sensorimotor cortical plasticity and pain, and may provide a novel treatment with BMI neurofeedback.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.