ArticleJournal of immunology (Baltimore, Md. : 1950)2016
PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 32 citations in OpenAlex.
- A Potent and Selective Quinolone-Based PTPN22 Inhibitor with Improved Immunotherapeutic Activity.Journal of medicinal chemistry · 2026Article
- The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis.Free radical biology & medicine · 2025Article
- Structure-activity relationship studies and design of a PTPN22 inhibitor with enhanced isozyme selectivity and cellular efficacy.European journal of medicinal chemistry · 2025Article
- Protein phosphatases in systemic autoimmunity.Immunometabolism (Cobham, Surrey) · 2025Review
- Regulation of T Cell Signaling and Immune Responses by PTPN22.Molecular and cellular biology · 2024Review
- Small molecule inhibitors for cancer immunotherapy and associated biomarkers - the current status.Frontiers in immunology · 2023Review
- Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy.Signal transduction and targeted therapy · 2022Review
- Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation.Frontiers in immunology · 2022Article
- Crosstalk between B cells and neutrophils in rheumatoid arthritis.Immunology · 2021Review
- Overexpression of theJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- A Darwinian View of Behçet's Disease.Rheumatology and immunology research · 2021Review
- De-coding genetic risk variants in type 1 diabetes.Immunology and cell biology · 2021Review
- The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment.Frontiers in immunology · 2021Article
- Influence ofFrontiers in immunology · 2021Review
- Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy.Journal for immunotherapy of cancer · 2020Article
- Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis.Mediators of inflammation · 2020Review
- PET Imaging of Liposomal Glucocorticoids usingTheranostics · 2020Article
- Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.Mucosal immunology · 2019Article
- A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.Clinical and experimental immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Neutrophils act as a first line of defense against bacterial and fungal infections, but they are also important effectors of acute and chronic inflammation. Genome-wide association studies have established that the gene encoding the protein tyrosine phosphatase nonreceptor 22 (PTPN22) makes an important contribution to susceptibility to autoimmune disease, notably rheumatoid arthritis. Although PTPN22 is most highly expressed in neutrophils, its function in these cells remains poorly characterized. We show in this article that neutrophil effector functions, including adhesion, production of reactive oxygen species, and degranulation induced by immobilized immune complexes, were reduced in Ptpn22
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.