Evidence map›Paper›PMID 27807073›Full record

ArticleCancer genomics & proteomics

Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals.

Elena Anzivino, Maria Antonella Zingaropoli, Marco Iannetta, Valeria Antonietta Pietropaolo, Alessandra Oliva, Francesco Iori, Antonio Ciardi, Donatella Maria Rodio, Francesca Antonini, Cesare Giovanni Fedele and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Elena AnzivinoDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Maria Antonella ZingaropoliDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Marco IannettaDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Valeria Antonietta PietropaoloDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Alessandra OlivaDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Francesco IoriDepartment of Obstretics, Gynecology and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Antonio CiardiDepartment of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy.
Donatella Maria RodioDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Francesca AntoniniDepartment of Obstretics, Gynecology and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Cesare Giovanni FedeleDiagnostic Microbiology Service National Center for Microbiology, Majadahonda, Madrid, Spain.
Alessandra D'AbramoDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Claudio Maria MastroianniDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Vincenzo VulloDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Maria Rosa CiardiDepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy maria.ciardi@uniroma1.it.
Sapienza University of Rome · ITCentro Nacional de Microbiologia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolyomaviruses (PyVs) are potential transforming viruses. Despite their involvement in human tumours still being debated, there is evidence to suggest a role for PyVs in bladder carcinoma (BC). Therefore, a possible association between PyVs and BC was investigated. MATERIALS AND

methodsUrine, blood and fresh bladder tissue specimens were collected from 29 patients with BC. PyV prevalence, non-coding control region (NCCR) organization and genotypic analysis were assessed.

resultsData showed a significant prevalence of John Cunningham (JC) PyV in BC tissues and in urine with respect to BKPyV, while simian virus 40 was not revealed. A BKPyV rearranged NCCR sequence was isolated, whereas a JCPyV archetypal structure was consistently retained. A prevalence of European genotypes was observed.

conclusionOur data would suggest a JCPyV involvement in cancer progression and a BKPyV association with BC pathogenesis in immunocompetent patients. However, further work is necessary to better understand the exact role of PyVs in urothelial carcinogenesis.

Indexed as

AgedAged, 80 and overBK VirusFemaleGene RearrangementGenotypeHumansJC VirusMaleMiddle AgedRNA, UntranslatedUrinary Bladder NeoplasmsUrotheliumRNA, UntranslatedBKPyVPolyomavirusesPyVsurothelial bladder carcinoma

Identifiers

PMID27807073
PMCPMC5219924
OpenAlexW2539978299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.