ArticleMolecular biology of the cell2017
HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition.
Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026Review
- Robust CENP-A incorporation in human cells is independent of transcription and cohesin components.Molecular biology of the cell · 2025Article
- Review
- HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization.Oncogene · 2024Article
- Contribution of CENP-F to FOXM1-Mediated Discordant Centromere and Kinetochore Transcriptional Regulation.Molecular and cellular biology · 2024Article
- NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.Journal of bioenergetics and biomembranes · 2023Article
- The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.Journal of cell science · 2023Article
- Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays.eLife · 2022Article
- The genetics and epigenetics of satellite centromeres.Genome research · 2022Article
- Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis.Current medical science · 2021Article
- RbAp46/48LIN-53 and HAT-1 are required for initial CENP-AHCP-3 deposition and de novo holocentromere formation on artificial chromosomes in Caenorhabditis elegans embryos.Nucleic acids research · 2021Article
- CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity.The Journal of cell biology · 2021Article
- Explore a novel function of human condensins in cellular senescence.Cell & bioscience · 2020Review
- HJURP knockdown disrupts clonogenic capacity and increases radiation-induced cell death of glioblastoma cells.Cancer gene therapy · 2020Article
- Tissue- and Sex-Specific DNA Methylation Changes in Mice Perinatally Exposed to Lead (Pb).Frontiers in genetics · 2020Article
- Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize.PLoS biology · 2020Article
- Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing.Nature communications · 2019Article
- The Oligomerization Landscape of Histones.Biophysical journal · 2019Article
- Centromere mechanical maturation during mammalian cell mitosis.Nature communications · 2019Article
- HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma.International journal of biological sciences · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Centromeric chromatin is required for kinetochore assembly during mitosis and accurate chromosome segregation. A unique nucleosome containing the histone H3-specific variant CENP-A is the defining feature of centromeric chromatin. In humans, CENP-A nucleosome deposition occurs in early G1 just after mitotic exit at the time when the CENP-A deposition machinery localizes to centromeres. The mechanism by which CENP-A is deposited onto an existing, condensed chromatin template is not understood. Here we identify the selective association of the CENP-A chaperone HJURP with the condensin II complex and not condensin I. We show CAPH2 is present at centromeres during early G1 at the time when CENP-A deposition is occurring. CAPH2 localization to early G1 centromeres is dependent on HJURP. The CENP-A chaperone and assembly factor HJURP induces decondensation of a noncentromeric LacO array, and this decondensation is modulated by the condensin II complex. We show that condensin II function at the centromere is required for new CENP-A deposition in human cells. These data demonstrate that HJURP selectively recruits the condensin II chromatin-remodeling complex to facilitate CENP-A deposition in human cells.
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