Trial reportThe American journal of clinical nutrition2016
Linear growth trajectories in Zimbabwean infants.
Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00198718 (Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery: Impact on Mother to Child Transmission of HIV During Lactation, HIV Infection Among Women During the Postpartum Year, and Infant Mortality.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Trial
- Maternal Characteristics Affect Fetal Growth Response in the Women First Preconception Nutrition Trial.Nutrients · 2019Trial
- A multicountry randomized controlled trial of comprehensive maternal nutrition supplementation initiated before conception: the Women First trial.The American journal of clinical nutrition · 2019Trial
- Article
- Latent classes of anthropometric growth in early childhood using uni- and multivariate approaches in a South African birth cohort.PloS one · 2025Article
- Growth-promoting hormonal alterations in pregnant women living with HIV receiving dolutegravir-based antiretroviral treatment are associated with lower infant 1-year weight z-scores.Frontiers in pediatrics · 2025Article
- Bifidobacterium longum and microbiome maturation modify a nutrient intervention for stunting in Zimbabwean infants.EBioMedicine · 2024Article
- When did the substantial loss of child linear growth occur?PloS one · 2023Article
- Growth and growth trajectory among infants in early life: contributions of food insecurity and water insecurity in rural Zimbabwe.BMJ nutrition, prevention & health · 2022Article
- Birth length is the strongest predictor of linear growth status and stunting in the first 2 years of life after a preconception maternal nutrition intervention: the children of the Women First trial.The American journal of clinical nutrition · 2022Article
- Child linear growth trajectories during the first three years of life in relation to infant iron status: a prospective cohort study in rural Vietnam.BMC nutrition · 2022Article
- Epidemiology of Underweight among Infants in Rural Burkina Faso.The American journal of tropical medicine and hygiene · 2021Article
- Determinants of growth in HIV-exposed and HIV-uninfected infants in the Kabeho Study.Maternal & child nutrition · 2019Article
- Child malnutrition in Ifanadiana district, Madagascar: associated factors and timing of growth faltering ahead of a health system strengthening intervention.Global health action · 2018Article
- Progress on growth faltering.The Lancet. Global health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundUndernutrition in early life underlies 45% of child deaths globally. Stunting malnutrition (suboptimal linear growth) also has long-term negative effects on childhood development. Linear growth deficits accrue in the first 1000 d of life. Understanding the patterns and timing of linear growth faltering or recovery during this period is critical to inform interventions to improve infant nutritional status.
objectiveWe aimed to identify the pattern and determinants of linear growth trajectories from birth through 24 mo of age in a cohort of Zimbabwean infants.
designWe performed a secondary analysis of longitudinal data from a subset of 3338 HIV-unexposed infants in the Zimbabwe Vitamin A for Mothers and Babies trial. We used k-means clustering for longitudinal data to identify linear growth trajectories and multinomial logistic regression to identify covariates that were associated with each trajectory group.
resultsFor the entire population, the mean length-for-age z score declined from -0.6 to -1.4 between birth and 24 mo of age. Within the population, 4 growth patterns were identified that were each characterized by worsening linear growth restriction but varied in the timing and severity of growth declines. In our multivariable model, 1-U increments in maternal height and education and infant birth weight and length were associated with greater relative odds of membership in the least-growth restricted groups (A and B) and reduced odds of membership in the more-growth restricted groups (C and D). Male infant sex was associated with reduced odds of membership in groups A and B but with increased odds of membership in groups C and D.
conclusionIn this population, all children were experiencing growth restriction but differences in magnitude were influenced by maternal height and education and infant sex, birth weight, and birth length, which suggest that key determinants of linear growth may already be established by the time of birth. This trial was registered at clinicaltrials.gov as NCT00198718.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.