Evidence map›Paper›PMID 27806972›Full record

Trial reportThe American journal of clinical nutrition2016

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial.

Hamed Samavat, April R Newman, Renwei Wang, Jian-Min Yuan, Anna H Wu, Mindy S Kurzer

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00917735 (Phase II, Randomized,Double-blind, Placebo-controlled, Study of the Efficacy of Green Tea Extract on Biomarkers of Breast Cancer Risk in High Risk Women With Differing Catechol-O-methyl Transferase), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00917735 phase2completednot on this map

Phase II, Randomized,Double-blind, Placebo-controlled, Study of the Efficacy of Green Tea Extract on Biomarkers of Breast Cancer Risk in High Risk Women With Differing Catechol-O-methyl Transferase (COMT) Genotypes

TypeinterventionalSponsorUniversity of MinnesotaRan2009 to 2014Enrolled1,075ConditionsBreast CancerArmsGreen tea extract supplement, Placebo
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
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  6. Trial
  7. Trial
  8. Nutrients · 2019
    Trial
  9. Trial
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Cholesterol Absorption Inhibition by Some Nutraceuticals.Recent advances in food, nutrition & agriculture · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hamed SamavatDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN.
April R NewmanDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN.
Renwei WangDivision of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
Jian-Min YuanDivision of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
Anna H WuDepartment of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA.
Mindy S KurzerDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN; mkurzer@umn.edu.
University of Minnesota · USUniversity of Pittsburgh · USUniversity of Southern California · USUPMC Hillman Cancer Center · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Green Tea and Reduction of Breast Cancer RiskR01CA127236 · NCI · UNIVERSITY OF MINNESOTA · PI KURZER, MINDY SUSAN · 2008 to 2013
$5.7M
Translational Research Training in Cancer Prevention and ControlT32CA186873 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kathryn H. Schmitz, Jian-Min Yuan · 2014 to 2026
$2.7M
NCATS NIH HHS UL1 TR000114NCI NIH HHS R01 CA127236NCI NIH HHS T32 CA186873
6 · The paper itself

Abstract

backgroundGreen tea has been suggested to improve cardiovascular disease risk factors, including circulating lipid variables. However, current evidence is predominantly based on small, short-term randomized controlled trials conducted in diverse populations.

objectiveThe aim of this study was to examine the efficacy and impact of green tea extract (GTE) supplementation high in epigallocatechin gallate (EGCG) on blood lipids in healthy postmenopausal women.

designThis was an ancillary study of a double-blind, randomized, placebo-controlled, parallel-arm trial investigating the effects of a GTE supplement containing 1315 mg catechins (843 mg EGCG) on biomarkers of breast cancer risk. Participants were randomly assigned to receive GTE (n = 538) or placebo (n = 537) and were stratified by catechol-O-methyltransferase (COMT) genotype activity (high COMT compared with low or intermediate COMT genotype activity). They consumed either 4 GTE or identical placebo capsules daily for 12 mo. A total of 936 women completed this substudy. Circulating lipid panels including total cholesterol (TC), HDL cholesterol, and triglycerides were measured at baseline and at months 6 and 12.

resultsCompared with placebo, 1-y supplementation with GTE capsules resulted in a significant reduction in circulating TC (-2.1% compared with 0.7%; P = 0.0004), LDL cholesterol (-4.1% compared with 0.9%; P < 0.0001) and non-HDL cholesterol (-3.1% compared with 0.4%; P = 0.0032). There was no change in HDL-cholesterol concentration, but triglyceride concentrations increased by 3.6% in the GTE group, whereas they decreased by 2.5% in the placebo group (P = 0.046). A significant reduction in TC was observed only among women with high (i.e., ≥200 mg/dL) baseline TC concentrations (P-interaction = 0.01) who consumed GTE capsules. The effect of GTE on the increase in triglycerides was mainly observed among obese women and statin users (P-interaction = 0.06).

conclusionSupplementation with GTE significantly reduced circulating TC and LDL-cholesterol concentrations, especially in those with elevated baseline TC concentrations. This trial was registered at clinicaltrials.gov as NCT00917735.

Indexed as

AntioxidantsBiomarkersBody Mass IndexCatechinCatechol O-MethyltransferaseCholesterol, HDLCholesterol, LDLDietary SupplementsDouble-Blind MethodFemaleHumansLipidsMiddle AgedObesityPlant ExtractsPostmenopauseAntioxidantsBiomarkersCatechinCatechol O-MethyltransferaseCholesterol, HDLCholesterol, LDLepigallocatechin gallateLipidsPlant ExtractsTeaTriglyceridesblood lipidscardiovascularEGCGgreen teapostmenopausalrandomized controlled trial

Identifiers

PMID27806972
PMCPMC5118731
OpenAlexW2547130884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.