Trial reportJournal of the American College of Surgeons2016
Effect of Patient Age on Outcomes in Breast Reconstruction: Results from a Multicenter Prospective Study.
Trial report in Journal of the American College of Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Postmastectomy Breast Reconstruction in Patients with Non-Metastatic Breast Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- Implants versus autologous tissue flaps for breast reconstruction following mastectomy.The Cochrane database of systematic reviews · 2024Pooled it
- Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review.The British journal of surgery · 2022Pooled it
- Quality of life after breast (reconstructive) surgery-an interim analysis of a prospective three-arm clinical trial with a 10-year follow-up (REKO 001).Archives of gynecology and obstetrics · 2026Trial
- Safety and Early Outcomes of Immediate Autologous Breast Reconstruction in Advanced Breast Cancer: An Indian Experience.European journal of breast health · 2026Article
- Patient satisfaction after breast reconstruction in a high-risk breast cancer population.JPRAS open · 2026Article
- Understanding Disparities in Breast Reconstruction Rates in Regional Populations Following Oncologic Resection of Breast Cancer: A 10-Year Retrospective Observational Cohort Study.The breast journal · 2026Observational
- Moving Toward the Outpatient DIEP Flap: Factors Influencing Early Discharge.Plastic and reconstructive surgery · 2025Article
- Influence of age on patient decision regret following breast reconstruction: a multicenter collaborative study in Japan.Breast cancer (Tokyo, Japan) · 2025Observational
- Patients' Perspectives on Breast Reconstruction in Sub-Saharan Africa.JAMA network open · 2025Article
- Quality of Life after Alloplastic versus Autologous Breast Reconstruction: The Influence of Patient Characteristics on Outcomes.Breast care (Basel, Switzerland) · 2025Article
- Satisfaction with Breasts following Autologous Reconstruction: Assessing Associated Factors and the Impact of Revisions.Plastic and reconstructive surgery · 2025Article
- Patient-reported outcomes 3 and 18 months after mastectomy and immediate prepectoral implant-based breast reconstruction in the UK Pre-BRA prospective multicentre cohort study.The British journal of surgery · 2025Article
- Normative BREAST-Q Scores in Sub-Saharan African Women: Interpreting the Impact of Mastectomy and Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- Age Impacts Clinical and Patient-Reported Outcomes following Postmastectomy Breast Reconstruction.Plastic and reconstructive surgery · 2025Article
- Breast cancer patients' postoperative outcomes in nipple-sparing mastectomy and reconstruction with subpectoral implant placement: a single center experience.Gland surgery · 2024Article
- Reducing Disparities: Regional Anesthesia Blocks for Mastectomy with Reconstruction Within Standardized Regional Anesthesia Pathways.Annals of surgical oncology · 2024Article
- A Randomized Controlled Trial of the Implementation of BREASTChoice , a Multilevel Breast Reconstruction Decision Support Tool With Personalized Risk Prediction.Annals of surgery · 2024Article
- Non-linear relationship between TyG index and the risk of prediabetes in young people: a 5-year retrospective cohort study in Chinese young adults.Frontiers in endocrinology · 2024Article
- Nipple-Sparing Mastectomies in Patients over the Age of 60 Years: Factors Associated with Surgical Outcomes.Annals of surgical oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough >40% of new breast cancer diagnoses in the US are in older women, few studies have assessed the outcomes of post-mastectomy reconstruction in this population. Our objective was to evaluate age effects on postoperative complications and patient-reported outcomes in women undergoing breast reconstruction, and to investigate whether age effects differ between reconstructive procedure types. STUDY
designEligible patients in the Mastectomy Reconstruction Outcomes Consortium study from 11 institutions (57 providers) in North America were analyzed. Two-year complications and patient-reported outcomes via BREAST-Q domains were compared across younger (younger than 45 years), middle-aged (45 to 60 years), and older (older than 60 years) women. Mixed-effects regression models were used, controlling for a range of demographic and clinical covariates.
resultsA total of 1,531 patients were studied: 494 younger, 803 middle-aged, and 234 older. Age was not a significant predictor of complications. For sexual well-being 2 years post-reconstruction, older women reported 4.25 (p = 0.04) higher mean scores with implant procedures, and 10.39 (p < 0.01) higher mean scores with autologous procedures compared with younger women. No age effect was seen with implant procedures with regard to physical and psychosocial well-being; however, older women who underwent autologous procedures reported 6.07 (p < 0.01) higher physical, and 8.21 (p < 0.01) higher psychosocial well-being scores than younger women.
conclusionsAge did not significantly affect complication rates. Older women demonstrated higher sexual well-being for both procedures, and better satisfaction and physical and psychosocial well-being than younger women with autologous procedures. Post-mastectomy reconstruction is a viable option for older patients, with risks and benefits comparable with those in younger women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.