ArticleMedical physics2016
Technical Note: Contrast free angiography of the pulmonary vasculature in live mice using a laboratory x-ray source.
Article in Medical physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Quantification of the pulmonary vasculature in mice under chronic hypoxia with contrast-free pulmonary angiography in vivo imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Innovations in thoracic imaging: CT, radiomics, AI and x-ray velocimetry.Respirology (Carlton, Vic.) · 2022Review
- Vascular Casting of Adult and Early Postnatal Mouse Lungs for Micro-CT Imaging.Journal of visualized experiments : JoVE · 2020Article
- Application of a novel in vivo imaging approach to measure pulmonary vascular responses in mice.Physiological reports · 2018Article
- Novel analysis of 4DCT imaging quantifies progressive increases in anatomic dead space during mechanical ventilation in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Pulmonary vessel casting in a rat model of monocrotaline-mediated pulmonary hypertension.Pulmonary circulationArticle
- Novel imaging approaches for small animal models of lung disease (2017 Grover Conference series).Pulmonary circulationArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeIn vivo imaging of the pulmonary vasculature in small animals is difficult yet highly desirable in order to allow study of the effects of a host of dynamic biological processes such as hypoxic pulmonary vasoconstriction. Here the authors present an approach for the quantification of changes in the vasculature.
methodsA contrast free angiography technique is validated in silico through the use of computer-generated images and in vivo through microcomputed tomography (μCT) of live mice conducted using a laboratory-based x-ray source. Subsequent image processing on μCT data allowed for the quantification of the caliber of pulmonary vasculature without the need for external contrast agents. These measures were validated by comparing with quantitative contrast microangiography in the same mice.
resultsQuantification of arterial diameters from the method proposed in this study is validated against laboratory-based x-ray contrast microangiography. The authors find that there is a high degree of correlation (R = 0.91) between measures from microangiography and their contrast free method.
conclusionsA technique for quantification of murine pulmonary vasculature without the need for contrast is presented. As such, this technique could be applied for longitudinal studies of animals to study changes to vasculature without the risk of premature death in sensitive mouse models of disease. This approach may also be of value in the clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.