Evidence map›Paper›PMID 27806297›Full record

ArticleCell reports2016

Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.

Xiao Yan, Heather A Himburg, Katherine Pohl, Mamle Quarmyne, Evelyn Tran, Yurun Zhang, Tiancheng Fang, Jenny Kan, Nelson J Chao, Liman Zhao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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  7. Endothelial mTOR maintains hematopoiesis during aging.The Journal of experimental medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xiao YanDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA.
Heather A HimburgDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA.
Katherine PohlDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA.
Mamle QuarmyneDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA.
Evelyn TranDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA.
Yurun ZhangDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA; Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Tiancheng FangDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA.
Jenny KanDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA.
Nelson J ChaoDivision of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC 27710, USA.
Liman ZhaoDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA.
Phuong L DoanDivision of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC 27710, USA.
John P ChuteDivision of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA. Electronic address: jchute@mednet.ucla.edu.
University of California, Los Angeles · USDuke University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
UCLA Center for Biological RadioprotectorsU19AI067769 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCBRIDE, WILLIAM H. · 2005 to 2019
$44.6M
Semaphorin signaling regulates vascular and hematopoietic regenerationR01HL086998 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P · 2008 to 2022
$4.6M
Epidermal growth factor mitigates radiation-induced hematopoietic failureU01AI107333 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P · 2013 to 2017
$2.6M
Role of ErbB receptor signaling in regulating normal and leukemic stem cell fateK08CA184552 · NCI · DUKE UNIVERSITY · PI DOAN, PHUONG LINH · 2014 to 2018
$639k
NCI NIH HHS K08 CA184552NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA021765NHLBI NIH HHS R01 HL086998NIAID NIH HHS U01 AI107333NIAID NIH HHS U19 AI067769NIAID NIH HHS U19 AI067798
6 · The paper itself

Abstract

Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulates hematopoietic stem cell (HSC) self-renewal and regeneration. Deletion of the maternal allele of Grb10 in mice (Grb10

Indexed as

Gene DeletionGenomic ImprintingRegenerationAnimalsBone Marrow CellsCell ProliferationCell Self RenewalGRB10 Adaptor ProteinHematopoietic Stem CellsMechanistic Target of Rapamycin Complex 1Mice, Inbred C57BLProto-Oncogene Proteins c-aktSignal TransductionWhole-Body IrradiationGRB10 Adaptor ProteinGrb10 protein, mouseMechanistic Target of Rapamycin Complex 1Proto-Oncogene Proteins c-aktadaptor proteinhematopoietic stem cellsimprinted generegenerationself-renewal

Identifiers

PMID27806297
PMCPMC5963255
OpenAlexW2548044639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.