Evidence map›Paper›PMID 27806296›Full record

ArticleCell reports2016

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.

Tiziano Donnarumma, George R Young, Julia Merkenschlager, Urszula Eksmond, Nadine Bongard, Stephen L Nutt, Claude Boyer, Ulf Dittmer, Vu Thuy Khanh Le-Trilling, Mirko Trilling and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 56 citations in OpenAlex.

  1. A new 'K'ind of T helper cell.Nature immunology · 2026
    Article
  2. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Cell Identity and Spatial Distribution of PD-1/PD-L1 Blockade Responders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Article
  9. The role of CD4MedComm · 2023
    Review
  10. Article
  11. Aiolos represses CD4Nature communications · 2023
    Article
  12. CD4Nature cancer · 2023
    Review
  13. TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity.International journal of molecular sciences · 2023
    Article
  14. Cytotoxic CD4Frontiers in immunology · 2023
    Review
  15. CD4Frontiers in immunology · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Cytotoxic CD4eLife · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Tiziano DonnarummaRetroviral Immunology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
George R YoungRetroviral Immunology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Retrovirus-Host Interactions, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Julia MerkenschlagerRetroviral Immunology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Urszula EksmondRetroviral Immunology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nadine BongardInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
Stephen L NuttThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Claude BoyerCentre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille 13288, France.
Ulf DittmerInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
Vu Thuy Khanh Le-TrillingInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
Mirko TrillingInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
Wibke BayerInstitute for Virology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
George KassiotisRetroviral Immunology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Medicine, Faculty of Medicine, Imperial College London, London W2 1PG, UK. Electronic address: george.kassiotis@crick.ac.uk.
University of Duisburg-Essen · DEThe Francis Crick Institute · GBCentre d’Immunologie de Marseille-Luminy · FRImperial College London · GBWalter and Eliza Hall Institute of Medical Research · AU

Funding

Cancer Research UK FC001099Medical Research Council FC001099Medical Research Council MC_U117581330
6 · The paper itself

Abstract

CD4

Indexed as

AnimalsCell Cycle CheckpointsGranzymesMiceProto-Oncogene Proteins c-bcl-6RetroviridaeT Cell Transcription Factor 1T-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerTranscription, GeneticGranzymesGzmb protein, mouseProto-Oncogene Proteins c-bcl-6T Cell Transcription Factor 1adenovirus-based vaccinationantiviral immunityCD4 T cell differentiationcytotoxic CD4 T cellsinhibitory receptorsretroviral infectionsingle-cell RNA sequencing

Identifiers

PMID27806296
PMCPMC5149578
OpenAlexW2548692573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.