ArticleCell reports2016
Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed.
- Learning reorganizes dendritic and stabilizes axon initial segment inhibitory synapses in CA1 pyramidal neurons.Nature communications · 2026Article
- Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons.Cell reports · 2026Article
- Syntaphilin Regulates Epithelial-Mesenchymal Transition and Metastasis in Gastric Cancer via the FAK/NF-κB/MMP-9 Signaling Pathway.International journal of molecular sciences · 2026Article
- A computational framework for epigenetic plasticity in memory.Brain : a journal of neurology · 2026Review
- The hippocampal CA3 area implements sequence learning of discontinuous episodes.Communications biology · 2026Article
- Engram Synapses and Synapse Dynamics in Memory Processing.Journal of neurochemistry · 2026Review
- Plastic Arbor: A modern simulation framework for synaptic plasticity-From single synapses to networks of morphological neurons.PLoS computational biology · 2026Article
- Brain and Immune System Part II-An Integrative View upon Spatial Orientation, Learning, and Memory Function.International journal of molecular sciences · 2025Review
- From Morphology to Computation: How Synaptic Organization Shapes Place Fields in CA1 Pyramidal Neurons.bioRxiv : the preprint server for biology · 2025Article
- Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time.Nature neuroscience · 2025Article
- Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning.Nature communications · 2025Article
- Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons.Frontiers in molecular neuroscience · 2025Article
- Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning.ArXiv · 2024Article
- The Role of Intrinsic Plasticity in Engram Physiology and Temporal Memory Linking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Article
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A realistic computational model for the formation of a Place Cell.Scientific reports · 2023Article
- Leveraging dendritic properties to advance machine learning and neuro-inspired computing.ArXiv · 2023Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery. Here, we develop a simplified, biophysically inspired network model that incorporates multiple plasticity processes and explains linking of information at three different levels: (1) learning of a single associative memory, (2) rescuing of a weak memory when paired with a strong one, and (3) linking of multiple memories across time. By dissecting synaptic from intrinsic plasticity and neuron-wide from dendritically restricted protein capture, the model reveals a simple, unifying principle: linked memories share synaptic clusters within the dendrites of overlapping populations of neurons. The model generates numerous experimentally testable predictions regarding the cellular and sub-cellular properties of memory engrams as well as their spatiotemporal interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.