Evidence map›Paper›PMID 27806256›Full record

ArticleStructure (London, England : 1993)2016

DNA Polymerase Fidelity: Beyond Right and Wrong.

M Todd Washington

Abstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. DNA Polymerase I Large Fragment fromInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

M Todd WashingtonDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: todd-washington@uiowa.edu.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Mechanisms of Damaged DNA Replication in EukaryotesR01GM081433 · NIGMS · UNIVERSITY OF IOWA · PI WASHINGTON, M. TODD · 2008 to 2021
$4.2M
NIGMS NIH HHS R01 GM081433
6 · The paper itself

Abstract

Accurate DNA replication depends on the ability of DNA polymerases to discriminate between correctly and incorrectly paired nucleotides. In this issue of Structure, Batra et al. (2016) show the structural basis for why DNA polymerases do not efficiently add correctly paired nucleotides immediately after incorporating incorrectly paired ones.

Indexed as

DNA ReplicationDNADNA-Directed DNA PolymeraseNucleotidesDNADNA-Directed DNA PolymeraseNucleotides

Identifiers

PMID27806256
PMCPMC5486402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.