ArticleAmerican journal of respiratory and critical care medicine2017
Electronic Cigarette Use and Respiratory Symptoms in Adolescents.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04616313 (Novel Pulmonary Imaging of Lung Structure and Function in Symptomatic and Asymptomatic E-cigarette Smokers), which is not on this map. Cited by 196 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Pulmonary Imaging of Lung Structure and Function in Symptomatic and Asymptomatic E-cigarette Smokers
Who cites it
196 citing papers in PubMed, 7 syntheses or guidelines pooled it, 385 citations in OpenAlex.
- Nicotine replacement therapy as a smoking cessation tool for adolescents: an update.Frontiers in psychiatry · 2025Pooled it
- Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes.NEJM evidence · 2024Pooled it
- A systematic review of the effects of e-cigarette use on lung function.NPJ primary care respiratory medicine · 2022Pooled it
- E-cigarette use and adverse respiratory symptoms among adolescents and Young adults in the United States.Preventive medicine · 2021Pooled it
- E-cigarette use and respiratory disorders: an integrative review of converging evidence from epidemiological and laboratory studies.The European respiratory journal · 2021Pooled it
- How effective are electronic cigarettes for reducing respiratory and cardiovascular risk in smokers? A systematic review.Harm reduction journal · 2020Pooled it
- Comparison of e-Cigarette and Cigarette Use and Dual Use Associations With Disease: Updated Systematic Review and Meta-Analysis.Public health reports (Washington, D.C. : 1974)Pooled it
- Adverse symptoms attributed to e-cigarettes over 6 months among participants of a randomized controlled trial testing nicotine free-base e-cigarettes for smoking cessation: secondary analysis of the ESTxENDS trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Trial
- The effect of nicotine delivery system on blood protease levels: a randomized crossover study.Scientific reports · 2025Trial
- Effect of nicotine mouth spray on urges to vape: A randomized, placebo-controlled, pharmacodynamic clinical trial in exclusive e-cigarette users.Addiction (Abingdon, England) · 2025Trial
- Identifying Promising Themes for Adolescent Vaping Warnings: A National Experiment.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Trial
- From Aerosol to Epithelium: An Integrated Clinical, Pathologic, and Mechanistic Review of Nicotine and Cannabis Vaporizer Use and Pulmonary Disease.Current allergy and asthma reports · 2026Review
- E-cigarette exposure triggers distal lung cell injury, persistent lung stress response, and antiviral immune suppression.JCI insight · 2026Article
- Oxidative Stress as a Potential Mechanistic Bridge Between Electronic Cigarette Components and Chronic Disease: A Combined Narrative and Bibliometric Analysis.Antioxidants (Basel, Switzerland) · 2026Review
- An updated pharmacovigilance evidence from U.S. tobacco problem reports following the FDA safety communication on e-cigarettes and seizures.BMC public health · 2026Article
- Prevalence and Mental Health Correlates of Electronic Cigarette Use Among Pediatric Primary Care Patients.Clinical pediatrics · 2026Article
- E-Cigarette Use Trajectories and Respiratory Symptoms in Adolescents and Young Adults: Sustained Use Linked to Greater Symptom Frequency.Journal of studies on alcohol and drugs · 2026Article
- Biomarkers of Exposure to Tobacco-Related Toxicants and Oxidative Stress Among Cancer Survivors.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Reforming schools into health promoting schools: perspective based on expert consensus from a European multistakeholder consultation.European journal of pediatrics · 2026Article
- Molecular Health Effects of Electronic Cigarettes.Biomolecules · 2026Review
136 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleRates of adolescent electronic (e-) cigarette use are increasing, but there has been little study of the chronic effects of use. Components of e-cigarette aerosol have known pulmonary toxicity.
objectivesTo investigate the associations of e-cigarette use with chronic bronchitis symptoms and wheeze in an adolescent population.
methodsAssociations of self-reported use of e-cigarettes with chronic bronchitic symptoms (chronic cough, phlegm, or bronchitis) and of wheeze in the previous 12 months were examined in 2,086 Southern California Children's Health Study participants completing questionnaires in 11th and 12th grade in 2014. MEASUREMENTS AND MAIN
resultsEver e-cigarette use was reported by 502 (24.0%), of whom 201 (9.6%) used e-cigarettes during the last 30 days (current users). Risk of bronchitic symptoms was increased by almost twofold among past users (odds ratio [OR], 1.85; 95% confidence interval [CI], 1.37-2.49), compared with never-users, and by 2.02-fold (95% CI, 1.42-2.88) among current users. Risk increased with frequency of current use (OR, 1.66; 95% CI, 1.02-2.68) for 1-2 days and 2.52 (95% CI, 1.56-4.08) for 3 or more days in past 30 days compared with never-users. Associations were attenuated by adjustment for lifetime number of cigarettes smoked and secondhand smoke exposure. However, risk of bronchitic symptoms among past e-cigarette users remained elevated after adjustment for relevant potential confounders and was also observed among never-cigarette users (OR, 1.70; 95% CI, 1.11-2.59). There were no statistically significant associations of e-cigarette use with wheeze after adjustment for cigarette use.
conclusionsAdolescent e-cigarette users had increased rates of chronic bronchitic symptoms. Further investigation is needed to determine the long-term effects of e-cigarettes on respiratory health.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.