ArticlePLoS pathogens2016
A Mouse Model of Chronic West Nile Virus Disease.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Gene expression profiles in neurological tissues during West Nile virus infection: a critical meta-analysis.BMC genomics · 2018Pooled it
- Adaptive immune response to West Nile virus infection in the Collaborative Cross mouse model: A database of cellular phenotypes and Quantitative Trait Loci.Scientific data · 2025Article
- Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses.Viruses · 2024Review
- African lineage 1a West Nile virus isolated from crocodiles exhibits low neuroinvasiveness in mice.The Journal of general virology · 2024Article
- Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19.Scientific reports · 2024Article
- Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19.Research square · 2024Article
- Mapping of susceptibility loci for Ebola virus pathogenesis in mice.Cell reports · 2024Article
- Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection.iScience · 2024Article
- Neuroinvasive Flavivirus Pathogenesis Is Restricted by Host Genetic Factors in Collaborative Cross Mice, Independently ofJournal of virology · 2023Article
- Interleukins, Chemokines, and Tumor Necrosis Factor Superfamily Ligands in the Pathogenesis of West Nile Virus Infection.Viruses · 2023Review
- Re-Examining the Importance of Pigs in the Transmission of Japanese Encephalitis Virus.Pathogens (Basel, Switzerland) · 2022Review
- Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.PLoS genetics · 2022Article
- Correlation of Regulatory T Cell Numbers with Disease Tolerance upon Virus Infection.ImmunoHorizons · 2021Article
- Host genetic control of natural killer cell diversity revealed in the Collaborative Cross.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.PLoS pathogens · 2021Article
- Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection.bioRxiv : the preprint server for biology · 2020Article
- Antipsychotic Behavioral Phenotypes in the Mouse Collaborative Cross Recombinant Inbred Inter-Crosses (RIX).G3 (Bethesda, Md.) · 2020Article
- Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.Cell reports · 2020Article
- Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections.International journal of molecular sciences · 2020Review
- Immune Predictors of Mortality After Ribonucleic Acid Virus Infection.The Journal of infectious diseases · 2020Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
Infection with West Nile virus (WNV) leads to a range of disease outcomes, including chronic infection, though lack of a robust mouse model of chronic WNV infection has precluded identification of the immune events contributing to persistent infection. Using the Collaborative Cross, a population of recombinant inbred mouse strains with high levels of standing genetic variation, we have identified a mouse model of persistent WNV disease, with persistence of viral loads within the brain. Compared to lines exhibiting no disease or marked disease, the F1 cross CC(032x013)F1 displays a strong immunoregulatory signature upon infection that correlates with restraint of the WNV-directed cytolytic response. We hypothesize that this regulatory T cell response sufficiently restrains the immune response such that a chronic infection can be maintained in the CNS. Use of this new mouse model of chronic neuroinvasive virus will be critical in developing improved strategies to prevent prolonged disease in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.