ArticlePloS one2016
Decreased Left Caudate Volume Is Associated with Increased Severity of Autistic-Like Symptoms in a Cohort of ADHD Patients and Their Unaffected Siblings.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Placental Insulin-like Growth Factor 1 Insufficiency Drives Neurodevelopmental Disorder-Relevant Behavioral Changes with Sex-Specific Vulnerabilities.bioRxiv : the preprint server for biology · 2026Article
- Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Subjective well-being can be predicted by caudate volume and promotion focus.Brain structure & function · 2024Article
- Influences of RASopathies on Neuroanatomical Variation in Children.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Specific brain imaging alterations underlying autistic traits in children with attention-deficit/hyperactivity disorder.Behavioral and brain functions : BBF · 2023Article
- Altered resting-state functional connectivity of the brain in children with autism spectrum disorder.Radiological physics and technology · 2023Article
- The cortico-striatal circuitry in autism-spectrum disorders: a balancing act.Frontiers in cellular neuroscience · 2023Review
- ASD symptoms in adults with ADHD: a comparative study using ADOS-2.European archives of psychiatry and clinical neuroscience · 2022Article
- Subcortical Brain Morphometry Differences between Adults with Autism Spectrum Disorder and Schizophrenia.Brain sciences · 2022Article
- Disorder-specific brain volumetric abnormalities in Attention-Deficit/Hyperactivity Disorder relative to Autism Spectrum Disorder.PloS one · 2020Article
- Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network.Translational psychiatry · 2019Article
- Combined Face-Brain Morphology and Associated Neurocognitive Correlates in Fetal Alcohol Spectrum Disorders.Alcoholism, clinical and experimental research · 2018Article
- Linking spatial gene expression patterns to sex-specific brain structural changes on a mouse model of 16p11.2 hemideletion.Translational psychiatry · 2018Article
- Inferior Frontal Gyrus Volume Loss Distinguishes Between Autism and (Comorbid) Attention-Deficit/Hyperactivity Disorder-A FreeSurfer Analysis in Children.Frontiers in psychiatry · 2018Article
- Multi-scale radiomic analysis of sub-cortical regions in MRI related to autism, gender and age.Scientific reports · 2017Article
- Structural brain imaging correlates of ASD and ADHD across the lifespan: a hypothesis-generating review on developmental ASD-ADHD subtypes.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
Corrections and comments
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Authors and funding
14 authors.
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Abstract
Autism spectrum disorder (ASD) symptoms frequently occur in individuals with attention-deficit/hyperactivity disorder (ADHD). While there is evidence that both ADHD and ASD have differential structural brain correlates, knowledge of the structural brain profile of individuals with ADHD with raised ASD symptoms is limited. The presence of ASD-like symptoms was measured by the Children's Social Behavior Questionnaire (CSBQ) in a sample of typically developing controls (n = 154), participants with ADHD (n = 239), and their unaffected siblings (n = 144) between the ages of 8 and 29. Structural magnetic resonance imaging (MRI) correlates of ASD ratings were analysed by studying the relationship between ASD ratings and grey matter volumes using mixed effects models which controlled for ADHD symptom count and total brain volume. ASD ratings were significantly elevated in participants with ADHD relative to controls and unaffected siblings. For the entire group (participants with ADHD, unaffected siblings and TD controls), mixed effect models revealed that the left caudate nucleus volume was negatively correlated with ASD ratings (t = 2.83; P = 0.005). The current findings are consistent with the role of the caudate nucleus in executive function, including the selection of goals based on the evaluation of action outcomes and the use of social reward to update reward representations. There is a specific volumetric profile associated with subclinical ASD-like symptoms in participants with ADHD, unaffected siblings and controls with the caudate nucleus and globus pallidus being of critical importance in predicting the level of ASD-like symptoms in all three groups.
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