ArticlePLoS neglected tropical diseases2016
Containing Ebola at the Source with Ring Vaccination.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Pooled it
- Identification and evaluation of epidemic prediction and forecasting reporting guidelines: A systematic review and a call for action.Epidemics · 2020Pooled it
- Comparing the effectiveness of ring and block-vaccination strategies on networks.PLoS computational biology · 2025Article
- Marburg virus outbreak: a global health threat, zoonotic risks, and the urgent need for international action.Virusdisease · 2025Article
- Reducing transmission in multiple settings is required to eliminate the risk of major Ebola outbreaks: a mathematical modelling study.Journal of the Royal Society, Interface · 2025Article
- Evaluating targeted COVID-19 vaccination strategies with agent-based modeling.PLoS computational biology · 2024Article
- Social Network Analysis of Ebola Virus Disease During the 2014 Outbreak in Sukudu, Sierra Leone.Open forum infectious diseases · 2022Article
- The ring vaccination trial design for the estimation of vaccine efficacy and effectiveness during infectious disease outbreaks.Clinical trials (London, England) · 2022Article
- Agent-based modelling of reactive vaccination of workplaces and schools against COVID-19.Nature communications · 2022Article
- Evaluating strategies for spatial allocation of vaccines based on risk and centrality.Journal of the Royal Society, Interface · 2022Article
- Assessing COVID-19 vaccination strategies in varied demographics using an individual-based model.Frontiers in public health · 2022Article
- Statistical Estimation of the Reproductive Number From Case Notification Data.American journal of epidemiology · 2021Review
- Ring vaccination of COVID-19 vaccines in medium- and high-risk areas of countries with low incidence of SARS-CoV-2 infection.Clinical and translational medicine · 2021Article
- The risk of SARS-CoV-2 outbreaks in low prevalence settings following the removal of travel restrictions.Communications medicine · 2021Article
- Coordinating SARS-CoV-2 genomic surveillance in the United States.Virus evolution · 2021Article
- A hybrid simulation model to study the impact of combined interventions on Ebola epidemic.PloS one · 2021Article
- Will an outbreak exceed available resources for control? Estimating the risk from invading pathogens using practical definitions of a severe epidemic.Journal of the Royal Society, Interface · 2020Article
- Role of modelling in COVID-19 policy development.Paediatric respiratory reviews · 2020Review
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
Interim results from the Guinea Ebola ring vaccination trial suggest high efficacy of the rVSV-ZEBOV vaccine. These findings open the door to the use of ring vaccination strategies in which the contacts and contacts of contacts of each index case are promptly vaccinated to contain future Ebola virus disease outbreaks. To provide a numerical estimate of the effectiveness of ring vaccination strategies we introduce a spatially explicit agent-based model to simulate Ebola outbreaks in the Pujehun district, Sierra Leone, structurally similar to previous modelling approaches. We find that ring vaccination can successfully contain an outbreak for values of the effective reproduction number up to 1.6. Through an extensive sensitivity analysis of parameters characterising the readiness and capacity of the health care system, we identify interventions that, alongside ring vaccination, could increase the likelihood of containment. In particular, shortening the time from symptoms onset to hospitalisation to 2-3 days on average through improved contact tracing procedures, adding a 2km spatial component to the vaccination ring, and decreasing human mobility by quarantining affected areas might contribute increase our ability to contain outbreaks with effective reproduction number up to 2.6. These results have implications for future control of Ebola and other emerging infectious disease threats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.