ArticlePsychosomatic medicine2017
Perceived Discrimination, Racial Identity, and Multisystem Stress Response to Social Evaluative Threat Among African American Men and Women.
Article in Psychosomatic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05820659 (Racial Discrimination and Dysregulated Stress Response), which is not on this map. Cited by 52 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Racial Discrimination and Dysregulated Stress Response: Risk/Protective Factors
Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Racial/Ethnic Discrimination and Cardiometabolic Diseases: A Systematic Review.Journal of racial and ethnic health disparities · 2024Pooled it
- A systematic review and meta-analysis of the Everyday Discrimination Scale and biomarker outcomes.Psychoneuroendocrinology · 2022Pooled it
- Links between discrimination and cardiovascular health among socially stigmatized groups: A systematic review.PloS one · 2019Pooled it
- Perceived Discrimination and Immunological Aging: A Systematic Review of Cellular and Molecular Markers.Biopsychosocial science and medicinePooled it
- Racial exclusion causes acute cortisol release among emerging-adult African Americans: The role of reduced perceived control.The Journal of social psychology · 2020Trial
- Intersection of Gender-Race/Color and Glycemic Control in Diabetes in Nine Years of Follow-up of the ELSA-Brazil Cohort.Journal of racial and ethnic health disparities · 2025Article
- Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation.Brain, behavior, & immunity - health · 2025Article
- Hormones, Stress, and Heart Disease in Transgender Women with HIV in LITE Plus.American journal of preventive medicine · 2025Observational
- The COVID-19 global pandemic and allostatic load among a cohort of Black and Latina transgender women living with HIV.Psychology of sexual orientation and gender diversity · 2025Article
- Impact of Structural Racism and Social Determinants of Health on Disparities in Breast Cancer Mortality.Cancer research · 2024Review
- Salivary uric acid dynamics are associated with stress response hormones among African Americans in an urban sample.Psychoneuroendocrinology · 2024Article
- Perceived Interpersonal Racism in Relation to Incident Coronary Heart Disease Among Black Women.Circulation · 2024Article
- C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sleep disorders and cancer incidence: examining duration and severity of diagnosis among veterans.Frontiers in oncology · 2024Article
- Associations Between Direct and Indirect Forms of Racism Exposure and Stress-Induced Inflammatory Response and Health in Pregnancy.Journal of racial and ethnic health disparities · 2023Article
- Research on Health Disparities: Strategies and Findings From the Black Women's Health Study.American journal of epidemiology · 2023Article
- Perceived Interpersonal Racism and Incident Stroke Among US Black Women.JAMA network open · 2023Article
- Incident racial discrimination predicts elevated C-Reactive protein in the Black Women's experiences Living with Lupus (BeWELL) study.Brain, behavior, and immunity · 2023Article
- HPA-SAM co-activation among racially diverse, economically disadvantaged early adolescents: Secondary analysis with a preliminary test of a multisystem, person-centered approach.Biological psychology · 2023Article
- By what molecular mechanisms do social determinants impact cardiometabolic risk?Clinical science (London, England : 1979) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveUnderstanding individual differences in the psychobiology of the stress response is critical to grasping how psychosocial factors contribute to racial and ethnic health disparities. However, the ways in which environmentally sensitive biological systems coordinate in response to acute stress is not well understood. We used a social-evaluative stress task to investigate coordination among the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and immune/inflammatory system in a community sample of 85 healthy African American men and women.
methodsSix saliva samples, 2 at each of baseline, event, and recovery phases of the stressor task, were assayed for cortisol, dehydroepiandrosterone-sulfate, salivary alpha-amylase, and salivary C-reactive protein. Individual differences in perceived discrimination and racial identity were also measured.
resultsFactor analysis demonstrated that stress systems were largely dissociated before stressor exposure but became aligned during event and recovery phases into functional biological stress responses (factor loadings ≥ .58). Coordinated responses were related to interactions of perceived discrimination and racial identity: when racial identity was strong, highly perceived discrimination was associated with low hypothalamic-pituitary-adrenal axis activity at baseline (B's = .68-.72, p < .001), low stress mobilization during the task (B's = .46-.62, p < .049), and a robust inflammatory response (salivary C-reactive protein) during recovery (B's = .72-.94, p < .002).
conclusionCulturally relevant social perceptions may be linked to a specific pattern of changing alignment in biological components of the stress response. Better understanding these links may significantly advance understanding of stress-related illnesses and disparities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.