ArticleThe Journal of clinical endocrinology and metabolism2017
Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan.
Article in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 114 citations in OpenAlex.
- A 30-year institutional experience of insulinoma management at a tertiary care center: a case series.Gland surgery · 2026Article
- Occult Insulinoma: A 19-Year Diagnostic Delay in a Patient With Recurrent Hypoglycemia.Cureus · 2026Article
- Unspecific clinical manifestations of insulinoma found in preoperative testing: a case report and narrative review.Frontiers in endocrinology · 2026Review
- Targeted near-infrared imaging utilizing a cathepsin-activated fluorophore for the intraoperative detection of canine insulinoma.PloS one · 2026Article
- Surgical Management of Sporadic Pancreatic Insulinomas in a Resource-Limited Setting: A Report of Two Cases.Case reports in surgery · 2026Article
- Rare pediatric insulinoma case diagnosed by endoscopic ultrasonography: insights into endogenous hyperinsulinemic hypoglycemia.Journal of pediatric endocrinology & metabolism : JPEM · 2025Article
- 28-Year-Old Woman With Undifferentiated Spells.Mayo Clinic proceedings · 2025Article
- Incidence and risk factors for insulinoma diagnosed in dogs under primary veterinary care in the UK.Scientific reports · 2025Article
- Insulinoma initially misdiagnosed as migraine.Archive of clinical cases · 2025Article
- Diagnosis and management of benign secreting pancreatic insulinoma: What's new? 4 case report.Rare tumors · 2025Article
- A Long Way to Find a Small Tumor: The Hunt for an Insulinoma.JCEM case reports · 2024Article
- Long-term Survival in a Child with Malignant Insulinoma After Liver TransplantationJournal of clinical research in pediatric endocrinology · 2024Article
- Clinicopathological Features of Insulinoma: A Single Tertiary Center Experience.Indian journal of surgical oncology · 2023Article
- DynamicQuantitative imaging in medicine and surgery · 2023Article
- Report of a Novel Molecular Profile in Malignant Insulinoma.Journal of clinical medicine · 2023Article
- Article
- Insulinoma-Accurate Preoperative Localization Is the Key to Management: An Initial Experience.Indian journal of surgical oncology · 2022Article
- Predictors and Outcomes of Minimally Invasive Surgery for Small Bowel Neuroendocrine Tumors : Minimally Invasive Surgery for SBNETs.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Clinical Management of Neuroendocrine Neoplasms in Clinical Practice: A Formal Consensus Exercise.Cancers · 2022Article
- Value ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Context: Reliable localization of insulinoma is critical for successful treatment. Objective: This study compared the accuracy of 68Gallium DOTA-(Tyr3)-octreotate (Ga-DOTATATE) positron emission tomography (PET)/computed tomography (CT) to anatomic imaging modalities, selective arterial secretagogue injection (SASI), and intraoperative ultrasound (IO ultrasound) and palpation for localizing insulinoma in patients who were biochemically cured. Design, Setting, and Patients: We conducted a retrospective analysis of 31 patients who had an insulinoma. The results of CT, magnetic resonance imaging (MRI), ultrasound, IO ultrasound, 68Ga-DOTATATE PET/CT, SASI, and operative findings were analyzed. Intervention, Main Outcome Measures, and Results: The insulinomas were correctly localized in 17 out of 31 (55%) patients by CT, in 17 out of 28 (61%) by MRI, in 6 out of 28 (21%) by ultrasound, and in 9 out of 10 (90%) by 68Ga-DOTATATE. In 29 of 31 patients (93.5%) who had IO ultrasound, an insulinoma was successfully localized. Thirty patients underwent SASI, and the insulinoma was regionalized in 28 out of 30 patients (93%). In 19 out of 23 patients (83%), manual palpation identified insulinoma. In patients who had all 4 noninvasive imaging studies, CT was concordant with 68Ga-DOTATATE in 6 out of 9 patients (67%), MRI in 8 out of 9 (78%), ultrasound in 0 out of 9; the lesion was only seen by 68Ga-DOTATATE in 1 out of 9 (11%). Conclusions: 68Ga-DOTATATE PET/CT identifies most insulinomas and may be considered as an adjunct imaging study when all imaging studies are negative and when a minimally invasive surgical approach is planned.
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