ArticleeLife2016
Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Generalized modality responses in primary sensory neurons of awake mice during the development of neuropathic pain.Frontiers in neuroscience · 2024Article
- Visualization of trigeminal ganglion sensory neuronal signaling regulated by Cdk5.Cell reports · 2022Article
- Modality-Specific Modulation of Temperature Representations in the Spinal Cord after Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- High-Throughput Functional Characterization of Visceral Afferents by Optical Recordings From Thoracolumbar and Lumbosacral Dorsal Root Ganglia.Frontiers in neuroscience · 2021Article
- scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3.Cellular and molecular gastroenterology and hepatology · 2021Article
- Sensitization of Cutaneous Primary Afferents in Bone Cancer Revealed by In Vivo Calcium Imaging.Cancers · 2020Article
- GCaMP as an indirect measure of electrical activity in rat trigeminal ganglion neurons.Cell calcium · 2020Article
- Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice.Gastroenterology · 2019Article
- Somatosensation a la mode: plasticity and polymodality in sensory neurons.Current opinion in physiology · 2019Article
- Optical recording reveals topological distribution of functionally classified colorectal afferent neurons in intact lumbosacral DRG.Physiological reports · 2019Article
- Peripheral Mechanisms Contributing to Osteoarthritis Pain.Current rheumatology reports · 2018Review
- Advances in understanding nociception and neuropathic pain.Journal of neurology · 2018Review
- Investigation of Pain Mechanisms by Calcium Imaging Approaches.Neuroscience bulletin · 2018Review
- Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- Article
- Article
- Calcium imaging for analgesic drug discovery.Neurobiology of pain (Cambridge, Mass.)Review
- Article
- Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic.Molecular painArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Inflammatory pain is thought to arise from increased transmission from nociceptors and recruitment of 'silent' afferents. To evaluate inflammation-induced changes, mice expressing GCaMP3 in cutaneous sensory neurons were generated and neuronal responses to mechanical stimulation in vivo before and after subcutaneous infusion of an 'inflammatory soup' (IS) were imaged in an unanesthetized preparation. Infusion of IS rapidly altered mechanical responsiveness in the majority of neurons. Surprisingly, more cells lost, rather than gained, sensitivity and 'silent' afferents that were mechanically insensitive and gained mechanosensitivity after IS exposure were rare. However, the number of formerly 'silent' afferents that became mechanosensitive was increased five fold when the skin was heated briefly prior to infusion of IS. These findings suggest that pain arising from inflamed skin reflects a dramatic shift in the balance of sensory input, where gains and losses in neuronal populations results in novel output that is ultimately interpreted by the CNS as pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.