ArticleAnalytical chemistry2016
Maximizing the Signal Gain of Electrochemical-DNA Sensors.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Seconds-resolved in vivo measurements reveal rapid, serotonin transporter-independent plasma serotonin clearance.Blood vessels, thrombosis & hemostasis · 2026Article
- Sequence-Dependent PNA-AgNP Bioconjugation Enables Electrochemical Discrimination of a Single-Base Mutation in Zika Virus RNA.ACS omega · 2026Article
- Charge-screening dominates signal transduction in electrochemical nucleic acid sensors for aminoglycosides.bioRxiv : the preprint server for biology · 2026Article
- Amplification-Free Detection of MiRNA Signatures in Milk: A Noninvasive Sensing Approach for Early Diagnosis of Bovine Mastitis.ACS measurement science au · 2026Article
- Data-Driven Electrochemistry Reveals the Impact of Hydrophobicity on Aptamer Cross-Reactivity.ACS measurement science au · 2026Article
- A Verilog-A-Based Redox-Signal Transduction Model for Co-Simulating Surface-Bound Electrochemical Biosensors and Circuits.IEEE transactions on biomedical circuits and systems · 2026Article
- On the Design, Fabrication, and Operation of Electrochemical Aptamer-Based Sensors.ACS sensors · 2025Review
- Advanced Nanomaterial-Based Electrochemical Biosensing of Loop-Mediated Isothermal Amplification Products.Biosensors · 2025Article
- Cost-effective, user-friendly detection and preconcentration of thrombin on a sustainable paper-based electrochemical platform.Analytical and bioanalytical chemistry · 2025Article
- Carboxylate-Terminated Electrode Surfaces Improve the Performance of Electrochemical Aptamer-Based Sensors.ACS applied materials & interfaces · 2025Article
- Modular DNA origami-based electrochemical detection of DNA and proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Electrochemical Aptamer-Based Biosensor for Detecting Pap31, a Biomarker for Carrion's Disease.Sensors (Basel, Switzerland) · 2024Article
- Label-free, real-time monitoring of cytochrome C drug responses in microdissected tumor biopsies with a multi-well aptasensor platform.Science advances · 2024Article
- Planar Disk μ-Aptasensors by Monolayer Assembly in a Dissolving Microdroplet.Analytical chemistry · 2024Article
- Nucleic acid-based wearable and implantable electrochemical sensors.Chemical Society reviews · 2024Review
- Comparison of voltammetric methods used in the interrogation of electrochemical aptamer-based sensors.Sensors & diagnostics · 2024Article
- Calibration-Free, Seconds-Resolved In Vivo Molecular Measurements using Fourier-Transform Impedance Spectroscopy Interrogation of Electrochemical Aptamer Sensors.ACS sensors · 2023Article
- Design of a printed electrochemical strip towards miRNA-21 detection in urine samples: optimization of the experimental procedures for real sample application.Analytical and bioanalytical chemistry · 2023Article
- FRET Imaging of Nonuniformly Distributed DNA SAMs on Gold Reveals the Role Played by the Donor/Acceptor Ratio and the Local Environment in Measuring the Rate of Hybridization.Chemical & biomedical imaging · 2023Article
- Rapid and Quantitative Detection of Lung Cancer Biomarker ENOX2 Using a Novel Aptamer in an Electrochemical DNA-Based (E-DNA) Biosensor.Biosensors · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Electrochemical DNA (E-DNA) sensors have emerged as a promising class of biosensors capable of detecting a wide range of molecular analytes (nucleic acids, proteins, small molecules, inorganic ions) without the need for exogenous reagents or wash steps. In these sensors, a binding-induced conformational change in an electrode-bound "probe" (a target-binding nucleic acid or nucleic-acid-peptide chimera) alters the location of an attached redox reporter, leading to a change in electron transfer that is typically monitored using square-wave voltammetry. Because signaling in this class of sensors relies on binding-induced changes in electron transfer rate, the signal gain of such sensors (change in signal upon the addition of saturating target) is dependent on the frequency of the square-wave potential pulse used to interrogate them, with the optimal square-wave frequency depending on the structure of the probe, the nature of the redox reporter, and other features of the sensor. Here, we show that, because it alters the driving force of the redox reaction and thus electron transfer kinetics, signal gain in this class of sensors is also strongly dependent on the amplitude of the square-wave potential pulse. Specifically, we show here that the simultaneous optimization of square-wave frequency and amplitude produces large (often more than 2-fold) increases in the signal gain of a wide range of E-DNA-type sensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.