Evidence map›Paper›PMID 27805055›Full record

ArticleScientific reports2016

Coenzyme Engineering of a Hyperthermophilic 6-Phosphogluconate Dehydrogenase from NADP

Hui Chen, Zhiguang Zhu, Rui Huang, Yi-Heng Percival Zhang

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Advanced Electroanalysis for Electrosynthesis.ACS organic & inorganic Au · 2024
    Review
  5. Review
  6. Article
  7. 6-Phosphogluconate dehydrogenase and its crystal structures.Acta crystallographica. Section F, Structural biology communications · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hui ChenBiological Systems Engineering Department, Virginia Tech, 304 Seitz Hall, Blacksburg, Virginia 24061, USA.
Zhiguang ZhuCell Free Bioinnovations Inc. 1800 Kraft Drive, Suite 222, Blacksburg, VA 24060, USA.
Rui HuangBiological Systems Engineering Department, Virginia Tech, 304 Seitz Hall, Blacksburg, Virginia 24061, USA.
Yi-Heng Percival ZhangBiological Systems Engineering Department, Virginia Tech, 304 Seitz Hall, Blacksburg, Virginia 24061, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineering the coenzyme specificity of redox enzymes plays an important role in metabolic engineering, synthetic biology, and biocatalysis, but it has rarely been applied to bioelectrochemistry. Here we develop a rational design strategy to change the coenzyme specificity of 6-phosphogluconate dehydrogenase (6PGDH) from a hyperthermophilic bacterium Thermotoga maritima from its natural coenzyme NADP

Indexed as

Amino Acid SequenceBacterial ProteinsBinding SitesBioelectric Energy SourcesCatalysisCoenzymesGenetic EngineeringModels, MolecularMolecular Docking SimulationMutagenesis, Site-DirectedNADNADPPhosphogluconate DehydrogenaseSubstrate SpecificityThermotoga maritimaBacterial ProteinsCoenzymesNADNADPPhosphogluconate Dehydrogenase

Identifiers

PMID27805055
PMCPMC5090862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.