ArticleScientific reports2016
Kisspeptin and RFRP-3 differentially regulate food intake and metabolic neuropeptides in the female desert jerboa.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Polystyrene Nanoparticles Cause Sex-Specific Toxicity in Male Zebrafish, Which Can Be Mitigated by Melatonin.Environmental toxicology · 2026Article
- Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.bioRxiv : the preprint server for biology · 2025Article
- The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.Endocrine reviews · 2024Review
- Food deprivation differentially modulates gene expression of LPXRFa and kisspeptin systems in the brain-pituitary axis of half-smooth tongue sole (Frontiers in endocrinology · 2023Article
- Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding.Pharmacology & therapeutics · 2022Review
- Article
- Overview and New Insights Into the Diversity, Evolution, Role, and Regulation of Kisspeptins and Their Receptors in Teleost Fish.Frontiers in endocrinology · 2022Review
- Direct effect of RFRP-3 microinjection into the lateral ventricle on the hypothalamic kisspeptin neurons in ovariectomized estrogen-primed rats.Experimental and therapeutic medicine · 2022Article
- RFamide peptides, the novel regulators of mammalian HPG axis: A review.Veterinary world · 2021Review
- Role of central kisspeptin and RFRP-3 in energy metabolism in the male Wistar rat.Journal of neuroendocrinology · 2021Article
- Metabolic regulation of kisspeptin - the link between energy balance and reproduction.Nature reviews. Endocrinology · 2020Review
- Novel insights into the metabolic action of Kiss1 neurons.Endocrine connections · 2020Review
- Circadian Regulation of the Brain and Behavior: A Neuroendocrine Perspective.Current topics in behavioral neurosciences · 2019Article
- Evidence for the Direct Effect of the NPFF Peptide on the Expression of Feeding-Related Factors in Spotted Sea Bass (Frontiers in endocrinology · 2019Article
- Functional Implications of RFRP-3 in the Central Control of Daily and Seasonal Rhythms in Reproduction.Frontiers in endocrinology · 2019Review
- Hindbrain dorsal vagal complex AMPK controls hypothalamic gluco-regulatory transmitter and counter-regulatory hormone responses to hypoglycemia.Brain research bulletin · 2019Article
- Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish.Frontiers in endocrinology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Jerboas are wild rodents exhibiting exceptional adaptation to their desert environment. Under harsh autumn conditions, they shut down reproduction, increase body weight and hibernate, while during spring they become sexually active even under negative energy-balance. We recently reported that these rhythms are associated with synchronized changes in genes expressing reproductive (Kiss1, Rfrp) and metabolic (Npy and Pomc) peptides, raising the hypothesis of coordinated seasonal regulation of both functions. Here we analyzed whether kisspeptin and RFRP-3 regulate food-intake in parallel to their established reproductive functions. Intracerebroventricular administration of kisspeptin inhibited food intake by 1.5-fold in fasted, but not ad-libitum fed, female jerboas captured in spring, an effect associated with an increase in Pomc and decrease in Rfrp mRNA levels. By contrast, intracerebroventricular injection of RFRP-3 induced a 4-fold increase in food-intake in ad-libitum female jerboas, together with a decrease in Pomc and increase in Npy mRNA levels. This orexigenic effect of RFRP-3 was observed in both spring and autumn, whereas kisspeptin's anorexigenic effect was only observed in spring. Altogether, this study reports opposite metabolic effects of kisspeptin and RFRP-3 in the female jerboa and strengthens our hypothesis of a coordinated, season-dependent, regulation of reproductive activity and food intake through interactions of these hypothalamic peptides.
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