SynthesisScientific reports2016
Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Genetic factors affect the susceptibility to bacterial infections in diabetes.Scientific reports · 2021Pooled it
- Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis.Parasitology research · 2019Pooled it
- Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines.Trends in microbiology · 2023Review
- Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations.American journal of human genetics · 2022Article
- Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis.PLoS pathogens · 2021Article
- Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens.Frontiers in physics · 2021Article
- These Are the Genes You're Looking For: Finding Host Resistance Genes.Trends in microbiology · 2021Review
- Deconvolution of intergenic polymorphisms determining high expression of Factor H binding protein in meningococcus and their association with invasive disease.PLoS pathogens · 2021Article
- Human genetics of meningococcal infections.Human genetics · 2020Review
- A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- RNA-Seq Data-Mining Allows the Discovery of Two Long Non-Coding RNA Biomarkers of Viral Infection in Humans.International journal of molecular sciences · 2020Article
- Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection.Journal of innate immunity · 2020Review
- Complement factor H contributes to mortality in humans and mice with bacterial meningitis.Journal of neuroinflammation · 2019Article
- Ancestry patterns inferred from massive RNA-seq data.RNA (New York, N.Y.) · 2019Article
- Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.Scientific reports · 2019Article
- Meningococcal Group B Vaccine For The Prevention Of Invasive Meningococcal Disease Caused ByInfection and drug resistance · 2019Article
- TIPICO IX: report of the 9Human vaccines & immunotherapeutics · 2019Article
- Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Review
- Article
- Invasive Meningococcal Disease in the Vaccine Era.Frontiers in pediatrics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 20 institutions in 5 countries.
Federico Martinón-TorresTranslational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, and GENVIP Research Group (www.genvip.org), Instituto de Investigación Sanitaria de Santiago, Galicia, Spain.
Eileen PngInfectious Diseases, Genome Institute of Singapore, Singapore.
Chiea Chuen KhorHuman Genetics, Genome Institute of Singapore, Singapore.
Sonia DavilaHuman Genetics, Genome Institute of Singapore, Singapore.
Victoria J WrightSection of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, UK.
Kar Seng SimHuman Genetics, Genome Institute of Singapore, Singapore.
Ana VegaFundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigaciones Sanitarias (IDIS), and Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
Laura FachalFundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigaciones Sanitarias (IDIS), and Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
David InwaldSection of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, UK.
Simon NadelSection of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, UK.
Enitan D CarrolInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Nazareth Martinón-TorresTranslational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, and GENVIP Research Group (www.genvip.org), Instituto de Investigación Sanitaria de Santiago, Galicia, Spain.
Sonia Marcos AlonsoTranslational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, and GENVIP Research Group (www.genvip.org), Instituto de Investigación Sanitaria de Santiago, Galicia, Spain.
Angel CarracedoFundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigaciones Sanitarias (IDIS), and Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
Elvira MorteruelUnidad de Cuidados Intensivos Pediátricos (UCIP), Hospital de Cruces, Bilbao, Spain.
Julio López-BayónUnidad de Cuidados Intensivos Pediátricos (UCIP), Hospital de Cruces, Bilbao, Spain.
Andrés Concha TorreUnidad de Cuidados Intensivos Pediátricos (UCIP), Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
Cristina Calvo MongeServicio de Pediatría, Hospital de Donostia, San Sebastián, Spain.
Pilar Azcón González de AguilarUnidad de Cuidados Intensivos Pediátricos (UCIP), Hospital Virgen de las Nieves de Granada, Granada, Spain.
Elisabeth Esteban TornéUnidad de Cuidados Intensivos Pediátricos, Hospital Sant Joan de Deu, Barcelona, Spain.
María Del Carmen Martínez-PadillaUnidad de Cuidados Intensivos Pediátricos, Complejo Hospitalario de Jaen, Spain.
José María Martinón-SánchezTranslational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, and GENVIP Research Group (www.genvip.org), Instituto de Investigación Sanitaria de Santiago, Galicia, Spain.
Michael LevinSection of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, UK.
Martin L HibberdInfectious Diseases, Genome Institute of Singapore, Singapore.
Antonio SalasTranslational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, and GENVIP Research Group (www.genvip.org), Instituto de Investigación Sanitaria de Santiago, Galicia, Spain.
ESIGEM network
ESPID meningococcal consortium – UK
EUCLIDS consortium members - Imperial College London (www.euclids-project.eu)
Imperial College London · GBInstituto de Investigación Sanitaria de Santiago · ESUniversidade de Santiago de Compostela · ESGenome Institute of Singapore · SGComplejo Hospitalario de Jaén · ESComplejo Hospitalario de Salamanca · ESHospital General Universitario Gregorio Marañón · ESHospital Virgen de la Salud · ESUniversity Hospital Complex Of Vigo · ESBiogipuzkoa Health Research Institute · ESComplejo Hospitalario Torrecárdenas · ESComplexo Hospitalario Universitario A Coruña · ESHospital de Cruces · ESMarqués de Valdecilla University Hospital · ESThe University of Sydney · AUUniversity of Cambridge · GBUniversity of Southampton · GBGenomics England · GBHospital Clínico Universitario de Valencia · ESHospital Sant Joan de Déu Barcelona · ES
Funding
MRF_ C0483Wellcome Trust
Abstract
Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs). The meta-analysis identified strong evidence of association (P-value ≤ 5 × 10
Indexed as
Genome-Wide Association StudyImmunity, InnateComplement Factor HDatabases, FactualGenetic LociGenotypeHumansMeningococcal InfectionsOdds RatioPolymorphism, Single NucleotideSpainWhite PeopleComplement Factor H
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.