ArticleScientific reports2016
Interactive effect of serum uric acid and total bilirubin for cardiovascular disease in Chinese patients with type 2 diabetes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Association between bilirubin levels with incidence and prognosis of stroke: A meta-analysis.Frontiers in neuroscience · 2023Article
- Bilirubin is inversely related to diabetic peripheral neuropathy assessed by sural nerve conduction study.Journal of diabetes investigation · 2021Article
- Serum bilirubin and ischaemic stroke: a review of literature.Stroke and vascular neurology · 2020Review
- Establishment of Clinical Prediction Model Based on the Study of Risk Factors of Stroke in Patients With Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2020Article
- Association Between Serum Bilirubin and the Progression of Carotid Atherosclerosis in Type 2 Diabetes.Journal of lipid and atherosclerosis · 2020Article
- Association of circulating total bilirubin level with ischemic stroke: a systemic review and meta-analysis of observational evidence.Annals of translational medicine · 2019Article
- Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?Journal of clinical laboratory analysis · 2018Article
- Interactive association of serum uric acid and total bilirubin with renal dysfunction among community-dwelling subjects.International urology and nephrology · 2017Article
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum uric acid (SUA) at high levels and bilirubin at low levels were potent antioxidant but it was uncertain that whether SUA and total bilirubin (TBIL) had additive interaction for the risk of CVD in type 2 diabetes mellitus (T2DM). We conducted a cross-sectional survey of 6713 inpatients with T2DM and admitted to 81 tertiary care hospitals. CVD was defined as having either prior coronary heart disease or stroke or peripheral arterial disease. Binary logistic regression was used to estimate odds ratios of SUA and TBIL for CVD. The effect size of additive interaction was estimated by three measures, i.e., relative excess risk due to interaction, attributable proportion due to interaction and synergy index. Among 6713 patients with T2DM, 561 (8.36%) suffered from CVD. Using ≥283 umol/L (median) to define high SUA and <11.5 umol/L (n = 2290 or 34.11%) to define low TBIL, copresence of both factors (n = 621 or 9.25%) was associated with 5.18-fold (95% CI, 4.00-6.72) risk of CVD with significant additive interactions in multivariable analysis as compared to absence of both risk factors. The copresence of both high SUA and low TBIL was associated with a large increased risk of CVD in high-risk Chinese patients with type 2 diabetes.
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