Trial reportObesity (Silver Spring, Md.)2016
Does Body Mass Index Modify Memory, Reasoning, and Speed of Processing Training Effects in Older Adults.
Trial report in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- The association between medial prefrontal GABA concentration and memory performance is disrupted in human with a high body mass index.Brain imaging and behavior · 2026Article
- High-Fat Diet Alters Behavior and Hippocampal Gene Expression.International journal of molecular sciences · 2025Article
- Body mass index predicts cognitive aging trajectories selectively for females: Evidence from the Victoria Longitudinal Study.Neuropsychology · 2020Article
- Prognostic factors for change in memory test performance after memory training in healthy older adults: a systematic review and outline of statistical challenges.Diagnostic and prognostic research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo describe 10-year trajectories of cognitive performance by body mass index (BMI) class and to investigate BMI differences in response to memory, reasoning, and speed of processing training in older adults.
methodsThis is a secondary analysis of the multisite, randomized trial Advanced Cognitive Training for Independent and Vital Elderly. There were 701 older adults with normal weight, 1,081 with overweight, and 902 with obesity (mean age 73.6) randomized to memory training, reasoning training, speed of processing training, or no-training control group. Participants completed memory, reasoning, and speed of processing tests. Baseline sociodemographic, health, and chronic disease measures were included as covariates in analyses.
resultsThe 10-year trajectories of memory, reasoning, or speed of processing performance did not differ by BMI status among the participants randomized to the untrained control arm. The training effect on the reasoning and speed of processing outcomes did not differ by BMI status. The training effect on the memory outcome in participants with a BMI indicating obesity, however, was just 38% of that observed in participants with normal-weight BMI.
conclusionsThese analyses of data from the largest trial of cognitive training ever conducted suggest that older adults with obesity may be less responsive to memory training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.