Evidence map›Paper›PMID 27804228›Full record

ArticleObesity (Silver Spring, Md.)2017

Genetic and neural predictors of behavioral weight loss treatment: A preliminary study.

Eunice Y Chen, Thomas M Olino, Chris J Conklin, Feroze B Mohamed, W Scott Hoge, Gary D Foster, Genetic and Neural Biomarkers of Obesity (GN-BO) study group:, Jean M Arlt, Kalina Eneva, Judy R Kidd and 7 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Precision medicine in adult and pediatric obesity: a clinical perspective.Therapeutic advances in endocrinology and metabolism · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Eunice Y ChenTemple Eating Disorders program (TEDp), Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Thomas M OlinoDepartment of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Chris J ConklinTemple University Magnetic Resonance Imaging Center, Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Feroze B MohamedTemple University Magnetic Resonance Imaging Center, Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
W Scott HogeDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Gary D FosterCenter for Obesity Research and Education, College of Public Health, Temple University, Philadelphia, Pennsylvania, USA.
Genetic and Neural Biomarkers of Obesity (GN-BO) study group:
Jean M ArltTemple Eating Disorders program (TEDp), Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Kalina EnevaTemple Eating Disorders program (TEDp), Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Judy R KiddDepartment of Genetics, Yale University, New Haven, Connecticut, USA.
Kenneth R KiddDepartment of Genetics, Yale University, New Haven, Connecticut, USA.
Michelle R LentDepartment of Psychiatry, Geisinger Obesity Institute, Danville, Pennsylvania, USA.
Susan MurrayTemple Eating Disorders program (TEDp), Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Andrew NewbergMyrna Brind Center of Integrative Medicine, Department of Radiology, Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania, USA.
Colleen TewksburyHospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stephanie S VanderVeurCenter for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Angelina YiuTemple Eating Disorders program (TEDp), Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Temple University · USYale University · USThomas Jefferson University · USThomas Jefferson University Hospital · USUniversity of Pennsylvania · USBrigham and Women's Hospital · USGeisinger Health System · USHospital of the University of Pennsylvania · US

Funding

Dialectical Behavior Therapy for Early Non-Responders to CBT with Binge Eating DiK23MH081030 · NIMH · UNIVERSITY OF CHICAGO · PI CHEN, EUNICE YU · 2008 to 2012
$686k
The Reward Neurocircuitry and Binge-Eating Disorder and Obesity - a Pilot StudyR21MH093932 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEN, EUNICE YU · 2012 to 2013
$406k
NIMH NIH HHS K23 MH081030NIMH NIH HHS R21 MH093932
6 · The paper itself

Abstract

objectiveTo examine neural mechanisms of action in behavioral weight loss treatment (BWL) and explore neural and genetic predictors of BWL.

methodsNeural activation to milkshake receipt and genetics were compared in 17 women with obesity who received 12 weeks of BWL and 17 women who received no intervention. Participants were scanned twice using functional magnetic resonance imaging at baseline and 12 weeks. Weight was assessed at baseline, 12, 36, and 60 weeks.

resultsBWL participants lost more weight than controls at 12 weeks (-4.82% versus -0.70%). After 12 weeks, BWL had greater reduction in right caudate activation response to milk shake receipt than did controls. Among BWL participants, baseline to 12-week reduction in frontostriatal activation to milk shake predicted greater weight loss at 12, 36, and 60 weeks. Possessing the A/A or T/A genotype of the fat mass and obesity-associated (FTO) variant rs9939609 predicted greater weight loss at 12 and 36 weeks.

conclusionsThese preliminary data reveal that reduction in right caudate activation may be a neural mechanism of weight loss in BWL, and baseline FTO variant and reduction in frontostriatal activation during BWL predict short- and long-term weight loss. These findings require replication in larger samples.

Indexed as

AdultBehavior TherapyBody Mass IndexBody WeightFemaleGenotypeHumansMiddle AgedObesityTreatment OutcomeWeight LossYoung Adult

Identifiers

PMID27804228
PMCPMC5381816
OpenAlexW2548279110

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.