Evidence map›Paper›PMID 27804067›Full record

Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2018

Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification with

Ran Klein, Adrian Ocneanu, Jennifer M Renaud, Maria C Ziadi, Rob S B Beanlands, Robert A deKemp

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Reducing motion-correction-induced variability inJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Trial
  2. Review
  3. Article
  4. Article
  5. Lower Extremity Flow Quantification Using DynamicIEEE transactions on radiation and plasma medical sciences · 2025
    Article
  6. Technical evaluation of immediate back-to-back rest-stress positron emission tomography scanning withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Pulmonary blood volume assessment from a standard cardiac rubidium-82 imaging protocol: impact of adenosine-induced hyperemia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  11. Review
  12. Activity regimes for 82Rb cardiac PET: Effects on absolute MBF and MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  13. The next step in improving (semi-)quantitative MPI PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  14. More evidence for adequate test-retest repeatability of myocardial blood flow quantification withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  15. Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3DEuropean journal of nuclear medicine and molecular imaging · 2021
    Article
  16. Article
  17. Measuring SPECT myocardial blood flow at the University of Ottawa Heart Institute.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  18. Internal validation of myocardial flow reserve PET imaging using stress/rest myocardial activity ratios with Rb-82 and N-13-ammonia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Observational
  19. Review
  20. Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ran KleinNational Cardiac PET Centre, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada. rklein@toh.on.ca.
Adrian OcneanuDepartment of Systems and Computer Engineering, Carleton University, Ottawa, Canada.
Jennifer M RenaudNational Cardiac PET Centre, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada.
Maria C ZiadiNational Cardiac PET Centre, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada.
Rob S B BeanlandsNational Cardiac PET Centre, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada.
Robert A deKempNational Cardiac PET Centre, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesQuantification of myocardial blood flow (MBF) and stress/rest flow reserve is used increasingly to diagnose multi-vessel coronary artery disease and micro-vascular disease with PET imaging. However, variability in the measurements may limit physician confidence to direct revascularization therapies based on specific threshold values. This study evaluated the effects of rubidium-82 (

method22 participants underwent single-session

resultsMBF values in the CA-CA group were more repeatable (smaller RPC

conclusionsConstant-activity-rate 'square-wave' infusion of

Indexed as

AgedCohort StudiesCoronary Artery DiseaseCoronary CirculationDipyridamoleExercise TestFemaleHumansMaleMiddle AgedMyocardial Perfusion ImagingPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesVasodilator AgentsDipyridamoleRadiopharmaceuticalsRubidium-82Rubidium RadioisotopesVasodilator Agentsmyocardial blood flowreproducibilityRubidium-82square-wave infusion profile

Identifiers

PMID27804067
PMCPMC5966478

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.