Evidence map›Paper›PMID 27804057›Full record

ArticleCancer causes & control : CCC2016

Body size over the life-course and the risk of endometrial cancer: the California Teachers Study.

Pamela L Horn-Ross, Alison J Canchola, Leslie Bernstein, Dennis Deapen, James V Lacey, Eunjung Lee, David O Nelson, Peggy Reynolds

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Pamela L Horn-RossCancer Prevention Institute of California, 2201 Walnut Ave., Suite 300, Fremont, CA, 94538, USA. pamhornross@gmail.com.
Alison J CancholaCancer Prevention Institute of California, 2201 Walnut Ave., Suite 300, Fremont, CA, 94538, USA.
Leslie BernsteinDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Dennis DeapenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angles, CA, USA.
James V LaceyDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Eunjung LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angles, CA, USA.
David O NelsonCancer Prevention Institute of California, Berkeley, CA, USA.
Peggy ReynoldsCancer Prevention Institute of California, Berkeley, CA, USA.
Cancer Prevention Institute of California · USUniversity of Southern California · USBeckman Research InstituteCity of Hope · US

Funding

CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS N01 PC035136NCI NIH HHS N02 PC015105NCI NIH HHS R01 CA077398
6 · The paper itself

Abstract

purposeObesity is a public health epidemic and a major risk factor for endometrial cancer. Here, we identify key aspects of body size which jointly, over the life-course (since adolescence), are associated with endometrial cancer risk.

methodsAmong 88,142 participants in the California Teachers Study, 887 were diagnosed with invasive type 1 endometrial cancer between 1997-1998 and 2012. Multivariable Cox proportional hazards models provided estimates of hazard rate ratios (HR) and 95% confidence intervals (CI) for endometrial cancer associated with life-course body size phenotypes, which incorporated validated measures.

resultsAmong women currently using hormone therapy, endometrial cancer risk was only associated with height (HR 1.78, 95% CI 1.32-2.40 for ≥67 vs. <67 inches). Among women not using hormone therapy, tall women who were overweight/obese in adolescence (HR 4.33, 95% CI 2.51-7.46) or who became overweight/obese as adults (HR 4.74, 95% CI 2.70-8.32) were at greatest risk.

conclusionsConsidering absolute body mass, changes in adiposity over time, and body fat distribution together, instead of each measure alone, we identified lifetime obesity phenotypes associated with endometrial cancer risk. These results more clearly define specific risk groups, and may explain inconsistent findings across studies, improve risk prediction models, and aid in developing targeted interventions for endometrial cancer.

Indexed as

Body SizeAdultBody Mass IndexCaliforniaEndometrial NeoplasmsFemaleHumansMiddle AgedObesityOverweightProportional Hazards ModelsRisk FactorsBody sizeEndometrial cancerHeightLife-courseObesity

Identifiers

PMID27804057
PMCPMC5134925
OpenAlexW2547828857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.