Evidence map›Paper›PMID 27803950›Full record

ArticleCellular and molecular life sciences : CMLS2017

Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy.

Ruud Weijer, Séverine Clavier, Esther A Zaal, Maud M E Pijls, Robert T van Kooten, Klaas Vermaas, René Leen, Aldo Jongejan, Perry D Moerland, Antoine H C van Kampen and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

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  15. Optimal Use of 2',7'-Dichlorofluorescein Diacetate in Cultured Hepatocytes.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  16. Effect of Photodynamic Therapy on Gemcitabine-Resistant CholangiocarcinomaFrontiers in cell and developmental biology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Ruud WeijerDepartment of Experimental Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
Séverine ClavierBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584, Utrecht, CH, The Netherlands.
Esther A ZaalBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584, Utrecht, CH, The Netherlands.
Maud M E PijlsDepartment of Experimental Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
Robert T van KootenDepartment of Experimental Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
Klaas VermaasBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584, Utrecht, CH, The Netherlands.
René LeenDepartment of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
Aldo JongejanBioinformatics Laboratory, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
Perry D MoerlandBioinformatics Laboratory, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
Antoine H C van KampenBioinformatics Laboratory, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
André B P van KuilenburgDepartment of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.
Celia R BerkersBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584, Utrecht, CH, The Netherlands.
Simone LemeerBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584, Utrecht, CH, The Netherlands.
Michal HegerDepartment of Experimental Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands. m.heger@amc.uva.nl.
University of Amsterdam · NLUtrecht University · NLAcademic Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is an established palliative treatment for perihilar cholangiocarcinoma that is clinically promising. However, tumors tend to regrow after PDT, which may result from the PDT-induced activation of survival pathways in sublethally afflicted tumor cells. In this study, tumor-comprising cells (i.e., vascular endothelial cells, macrophages, perihilar cholangiocarcinoma cells, and EGFR-overexpressing epidermoid cancer cells) were treated with the photosensitizer zinc phthalocyanine that was encapsulated in cationic liposomes (ZPCLs). The post-PDT survival pathways and metabolism were studied following sublethal (LC

Indexed as

Metabolic Networks and PathwaysPhotochemotherapySignal TransductionAnimalsCell DeathCell LineCell SurvivalDown-RegulationEnergy MetabolismErbB ReceptorsHumansMetabolomeMetabolomicsMiceOxidation-ReductionPhotosensitizing AgentsErbB ReceptorsPhotosensitizing AgentsCancer therapyMetallated phthalocyaninesNon-resectable perihilar cholangiocarcinomaReactive oxygen speciesTherapeutic recalcitranceTumor targeting

Identifiers

PMID27803950
PMCPMC5309296
OpenAlexW2547534421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.