Evidence map›Paper›PMID 27803872›Full record

ReviewInternational journal of ophthalmology2016

Age-related changes in the kinetics of human lenses: prevention of the cataract.

Nicola Pescosolido, Andrea Barbato, Rossella Giannotti, Chiara Komaiha, Fiammetta Lenarduzzi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Application of Silicone in Ophthalmology: A Review.Materials (Basel, Switzerland) · 2024
    Review
  12. Glycative stress as a cause of macular degeneration.Progress in retinal and eye research · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. The Possible Positive Mechanisms of Pirenoxine in Cataract Formation.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicola PescosolidoDepartment of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Andrea BarbatoDepartment of Sense Organs, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Rossella GiannottiDepartment of Sense Organs, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Chiara KomaihaDepartment of Sense Organs, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Fiammetta LenarduzziDepartment of Sense Organs, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The crystalline lens is a transparent, biconvex structure in the eye that, along with the cornea, helps to refract light to be focused on the retina and, by changing shape, it adjusts focal distance (accommodation). The three classes of structural proteins found in the lens are α, β, and γ crystallins. These proteins make up more than 90% of the total dry mass of the eye lens. Other components which can be found are sugars, lipids, water, several antioxidants and low weight molecules. When ageing changes occur in the lens, it causes a gradual reduction in transparency, presbyopia and an increase in the scattering and aberration of light waves as well as a degradation of the optical quality of the eye. The main changes that occur with aging are: 1) reduced diffusion of water from the outside to the inside of the lens and from its cortical to its nuclear zone; 2) crystalline change due to the accumulation of high molecular weight aggregates and insoluble proteins; 3) production of advanced glycation end products (AGEs), lipid accumulation, reduction of reduced glutathione content and destruction of ascorbic acid. Even if effective strategies in preventing cataract onset are not already known, good results have been reached in some cases with oral administration of antioxidant substances such as caffeine, pyruvic acid, epigallocatechin gallate (EGCG), α-lipoic acid and ascorbic acid. Furthermore, methionine sulfoxide reductase A (MSRA) over expression could protect lens cells both in presence and in absence of oxidative stress-induced damage. Nevertheless, promising results have been obtained by reducing ultraviolet-induced oxidative damage.

Indexed as

antioxidantscataractcrystallineeye lenskynureninesultraviolet radiations

Identifiers

PMID27803872
PMCPMC5075670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.