ArticleIranian journal of basic medical sciences2016
The Expression implication of GDNF in ventral horn and associated remote cortex in rhesus monkeys with hemisected spinal cord injury.
Article in Iranian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Spatial and temporal immunoreactivity in the rat brain using an affinity purified polyclonal antibody to DNSP-11.Journal of chemical neuroanatomy · 2019Article
- Protein Network Analysis of the Serum and Their Functional Implication in Patients Subjected to Traumatic Brain Injury.Frontiers in neuroscience · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
objectivesGlial cell line-derived neurotrophic factor (GDNF) can effectively promote axonal regeneration, limit axonal retraction, and produce a statistically significant improvement in motor recovery after spinal cord injury (SCI). However, the role in primate animals with SCI is not fully cognized. MATERIALS AND
methods18 healthy juvenile rhesuses were divided randomly into six groups, observed during the periods of 24 hr, 7 days, 14 days, 1 month, 2 months, and 3 months after T11 hemisecting. The GDNF localization, changes in the injured region, and the remote associate cortex were detected by immunohistochemical staining.
resultsImmunohistochemical staining showed that GDNF was located in the cytoplasm and the neurite of the neurons. Following SCI, the number of GDNF positive neurons in the ventral horn and the caudal part near the lesion area were apparently reduced at detected time points (
conclusionTo sum up, GDNF disruption in neurons occurred after SCI especially in cortex motor area. Intrinsic GDNF in the spinal cord, plays an essential role in neuroplasticity. Thereafter extrinsic GDNF supplementing may be a useful strategy to promote recovery after SCI.
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27803784PMC5080427W2524731735What OpenQuestion holds
Registered trials
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