ArticleAnnals of thoracic medicine
Ketamine versus aminophylline for acute asthma in children: A randomized, controlled trial.
Article in Annals of thoracic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies.European journal of clinical pharmacology · 2022Pooled it
- Interventions for escalation of therapy for acute exacerbations of asthma in children: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2020Pooled it
- Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis.Drug design, development and therapy · 2018Pooled it
- Ketamine for management of acute exacerbations of asthma in children.The Cochrane database of systematic reviews · 2012Pooled it
- Ketamine for Severe Asthma Exacerbation.Critical care explorations · 2026Observational
- Open and Closed Triple Inhaler Therapy in Patients with Uncontrolled Asthma.Advances in respiratory medicine · 2023Review
- Review
- The effects of nebulized ketamine and intravenous magnesium sulfate on corticosteroid resistant asthma exacerbation; a randomized clinical trial.Asthma research and practice · 2021Article
- [Paediatric Life Support].Notfall & rettungsmedizin · 2021Review
- Treating acute severe asthma attacks in children: using aminophylline.Breathe (Sheffield, England) · 2020Article
- Out-of-hospital ketamine: review of a growing trend in patient care.Journal of the American College of Emergency Physicians open · 2020Review
- MTOR-Mediated Autophagy Is Involved in the Protective Effect of Ketamine on Allergic Airway Inflammation.Journal of immunology research · 2019Article
- Paediatrics: messages from Munich.ERJ open research · 2015Article
- Repurposing Potential of Ketamine: Opportunities and Challenges.Indian journal of psychological medicineReview
- The Saudi Initiative for Asthma - 2019 Update: Guidelines for the diagnosis and management of asthma in adults and children.Annals of thoracic medicineArticle
- The Saudi initiative for asthma - 2024 update: Guidelines for the diagnosis and management of asthma in adults and children.Annals of thoracic medicineArticle
- The Saudi Initiative for Asthma - 2021 Update: Guidelines for the diagnosis and management of asthma in adults and children.Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a lack of consensus regarding second-line therapy in children with acute asthma who fail to the standard therapy. Ketamine had bronchodilator property and may be useful in the treatment of acute asthma.
objectiveThe objective of this study was to evaluate the efficacy and safety of ketamine as compared to aminophylline in children with acute asthma who respond poorly to the standard therapy.
methodsThis randomized controlled trial included patients with acute asthma having Pediatric Respiratory Assessment Measure (PRAM) score ≥5 at 2 h of standard therapy. The enrolled patients received either intravenous (IV) ketamine or IV aminophylline. Primary outcome measure was change in PRAM score at the end of intervention. Secondary outcome measures included adverse effects, change in PO
resultsThe trial included 24 patients each in ketamine and aminophylline groups. The baseline parameters were similar between the groups. The primary outcome was similar in both the groups with a change in PRAM score of 4.00 ± 1.25 and 4.17 ± 1.68 (
conclusionKetamine and aminophylline were equally effective for children with acute asthma who responded poorly to the standard therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.