ArticleAnnals of thoracic medicine
The diagnostic significance of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 levels in pulmonary embolism.
Article in Annals of thoracic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06733961 (Investigation of the Relationship of SCUBE-1 and VAP-1 Levels on Diagnosis, Prognosis and Clinical Results in Patients With Pulmonary Thromboembolism Diagnosis in Emergency Department), which is not on this map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Relationship of SCUBE-1 and VAP-1 Levels on Diagnosis, Prognosis and Clinical Results in Patients With Pulmonary Thromboembolism Diagnosis in Emergency Department
Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Are Signal Peptides Hidden Regulators of Neurodegenerative Disease?Biomedicines · 2026Review
- Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design.Vaccines · 2025Review
- Naringin in cholestatic liver ischemia-reperfusion injury.Acta cirurgica brasileira · 2025Article
- Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- The diagnostic potential of plasma SCUBE-1 concentration for pulmonary embolism: A pilot study.The clinical respiratory journal · 2023Article
- Upregulation of Inflammatory Cytokines in Pulmonary Embolism Using Biochip-Array Profiling.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed.
aimThe aim of our study was to investigate the role of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) used in the diagnosis of PE.
methodsThe study was designed prospectively. A total of 57 patients who were admitted to emergency service with clinically suspected PE were included in the study. The patients diagnosed with PE were defined as PE group (
resultsMean SCUBE1 levels were higher in the PE group (0.90 ng/mL) than in the non-PE (0.38 ng/mL) and control groups (0.47 ng/mL) (
conclusionThis study suggests that serum SCUBE1 measurement might be used as a diagnostic biomarker in PE.
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