ArticleProceedings of the National Academy of Sciences of the United States of America2016
Genetic architecture of nonadditive inheritance in Arabidopsis thaliana hybrids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed.
- From reference-genome prediction to causal generalization: sequence-to-function models for plant regulatory genomics.Frontiers in plant science · 2026Review
- Powerful one-dimensional scan to detect heterotic quantitative trait loci.Nature communications · 2025Article
- From Individual to Stand Performance in Hybrids: Challenging the Optimal Parental Genetic Distance.Evolutionary applications · 2025Article
- GWAS-based population genetic analysis identifies bZIP29 as a heterotic gene in maize.Plant communications · 2025Article
- The haplotype-resolved T2T genome for Bauhinia × blakeana sheds light on the genetic basis of flower heterosis.GigaScience · 2025Article
- The genetic architecture of gene expression regulation in aFrontiers in plant science · 2025Article
- A higher-yield hybrid rice is achieved by assimilating a dominant heterotic gene in inbred parental lines.Plant biotechnology journal · 2024Article
- The mRNA-lncRNA landscape of multiple tissues uncovers key regulators and molecular pathways that underlie heterosis for feed intake and efficiency in laying chickens.Genetics, selection, evolution : GSE · 2023Article
- Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.Genome biology · 2023Article
- Pervasive under-dominance in gene expression underlying emergent growth trajectories in Arabidopsis thaliana hybrids.Genome biology · 2023Article
- Heritability of temperature-mediated flower size plasticity inQuantitative plant biology · 2023Article
- Combined population transcriptomic and genomic analysis reveals cis-regulatory differentiation of non-coding RNAs in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Large-scale genomic and transcriptomic profiles of rice hybrids reveal a core mechanism underlying heterosis.Genome biology · 2022Article
- Transcriptome Analyses Indicate Significant Association of Increased Non-Additive and Allele-Specific Gene Expression with Hybrid Weakness in Rice (Life (Basel, Switzerland) · 2022Article
- Integrating genome-wide association mapping of additive and dominance genetic effects to improve genomic prediction accuracy in Eucalyptus.The plant genome · 2022Article
- Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations.Molecular biology and evolution · 2022Article
- Genetic Basis of Sexual Maturation Heterosis: Insights From Ovary lncRNA and mRNA Repertoire in Chicken.Frontiers in endocrinology · 2022Article
- Parent-of-Origin Effects on Seed Size Modify Heterosis Responses inFrontiers in plant science · 2022Article
- Advances in lentil production through heterosis: Evaluating generations and breeding systems.PloS one · 2022Article
- Genetic basis of negative heterosis for growth traits in chickens revealed by genome-wide gene expression pattern analysis.Journal of animal science and biotechnology · 2021Article
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10 authors.
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Abstract
The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over a century and is of considerable agricultural importance. Although examples of both phenomena have been subject to intense investigation, no general model for the molecular basis of nonadditive genetic variance has emerged, and prediction of hybrid phenotypes from parental information continues to be a challenge. Here we explore the genetics of hybrid phenotype in 435 Arabidopsis thaliana individuals derived from intercrosses of 30 parents in a half diallel mating scheme. We find that nonadditive genetic effects are a major component of genetic variation in this population and that the genetic basis of hybrid phenotype can be mapped using genome-wide association (GWA) techniques. Significant loci together can explain as much as 20% of phenotypic variation in the surveyed population and include examples that have both classical dominant and overdominant effects. One candidate region inherited dominantly in the half diallel contains the gene for the MADS-box transcription factor AGAMOUS-LIKE 50 (AGL50), which we show directly to alter flowering time in the predicted manner. Our study not only illustrates the promise of GWA approaches to dissect the genetic architecture underpinning hybrid performance but also demonstrates the contribution of classical dominance to genetic variance.
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