Evidence map›Paper›PMID 27803316›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Selvamicin, an atypical antifungal polyene from two alternative genomic contexts.

Ethan B Van Arnam, Antonio C Ruzzini, Clarissa S Sit, Heidi Horn, Adrián A Pinto-Tomás, Cameron R Currie, Jon Clardy

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 126 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ethan B Van ArnamDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Antonio C RuzziniDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Clarissa S SitDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Heidi HornDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706.
Adrián A Pinto-TomásCentro de Investigación en Estructuras Microscópicas, Universidad de Costa Rica, San Pedro de Montes de Oca 2060, Costa Rica.
Cameron R CurrieDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jon_clardy@hms.harvard.edu.
Harvard University · USUniversity of Wisconsin–Madison · USUniversidad de Costa Rica · CR

Funding

Metabolomics driven discovery of drug leads from symbiotic bacteriaU19AI109673 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, CURRIE, CAMERON ROBERT · 2014 to 2018
$16.2M
Molecule-to-gene approaches to new natural productsR01GM086258 · NIGMS · HARVARD MEDICAL SCHOOL · PI CLARDY, JON · 2008 to 2016
$3.6M
Chemical biology of bacterial symbiontsR01AT009874 · NCCIH · HARVARD MEDICAL SCHOOL · PI CLARDY, JON · 2017 to 2019
$1.2M
Chemical Biology of Ant-Associated Defensive BacteriaF32GM117661 · NIGMS · HARVARD MEDICAL SCHOOL · PI VAN ARNAM, ETHAN BUGGIE · 2016 to 2017
$65k
CIHRNCCIH NIH HHS R01 AT009874NIAID NIH HHS U19 AI109673NIGMS NIH HHS F32 GM117661NIGMS NIH HHS R01 GM086258
6 · The paper itself

Abstract

The bacteria harbored by fungus-growing ants produce a variety of small molecules that help maintain a complex multilateral symbiosis. In a survey of antifungal compounds from these bacteria, we discovered selvamicin, an unusual antifungal polyene macrolide, in bacterial isolates from two neighboring ant nests. Selvamicin resembles the clinically important antifungals nystatin A

Indexed as

ActinobacteriaAnimalsAntifungal AgentsAntsCandida albicansGene Transfer, HorizontalGenome, BacterialGenomicsGlycosylationMacrolidesMultigene FamilyPlasmidsPolyenesAntifungal AgentsMacrolidesPolyenesselvamicinantifungalbiosynthesishorizontal gene transfernatural productssymbiosis

Identifiers

PMID27803316
PMCPMC5135293
OpenAlexW2547632626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.