ArticleSocial cognitive and affective neuroscience2017
Neural correlates of appetitive extinction in humans.
Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Reward-enhanced encoding improves relearning of forgotten associations.Scientific reports · 2018Trial
- Neural correlates of appetitive extinction learning: an fMRI study with actively participating pigeons.Scientific reports · 2026Article
- Measuring Human Pavlovian Reward Conditioning and Memory Retention After Consolidation.Psychophysiology · 2025Article
- Enhanced conditioning and disrupted extinction processes in men struggling with compulsive sexual behaviors.Journal of behavioral addictions · 2025Article
- Transcranial direct-current stimulation enhances Pavlovian tendencies during intermittent loss of control.Frontiers in psychiatry · 2023Article
- Amygdala and nucleus accumbens involvement in appetitive extinction.Human brain mapping · 2020Article
- Generalization of appetitive conditioned responses.Psychophysiology · 2019Article
- Relationship of sensation seeking with the neural correlates of appetitive conditioning.Social cognitive and affective neuroscience · 2019Article
- Attributed social context and emotional content recruit frontal and limbic brain regions during virtual feedback processing.Cognitive, affective & behavioral neuroscience · 2019Article
- The Cognitive Control of Eating and Body Weight: It's More Than What You "Think".Frontiers in psychology · 2019Review
- The emerging neuroscience of appetitive and drug cue extinction in humans.Psychopharmacology · 2019Review
- Translational tests involving non-reward: methodological considerations.Psychopharmacology · 2019Review
- Neural correlates of subjective CS/UCS association in appetitive conditioning.Human brain mapping · 2018Article
- Pitch Syntax Violations Are Linked to Greater Skin Conductance Changes, Relative to Timbral Violations - The Predictive Role of the Reward System in Perspective of Cortico-subcortical Loops.Frontiers in psychology · 2017Article
- Trait self-compassion enhances activation in the medial prefrontal cortex during fear extinction: An fNIRS study.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
4 authors.
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Abstract
Appetitive extinction receives attention as an important model for the treatment of psychiatric disorders. However, in humans, its underlying neural correlates remain unknown. To close this gap, we investigated appetitive acquisition and extinction with fMRI in a 2-day monetary incentive delay paradigm. During appetitive conditioning, one stimulus (CS+) was paired with monetary reward, while another stimulus (CS-) was never rewarded. Twenty-four hours later, subjects underwent extinction, in which neither CS was reinforced. Appetitive conditioning elicited stronger skin conductance responses to the CS+ as compared with the CS-. Regarding subjective ratings, the CS+ was rated more pleasant and arousing than the CS- after conditioning. Furthermore, fMRI-results (CS+ - CS-) showed activation of the reward circuitry including amygdala, midbrain and striatal areas. During extinction, conditioned responses were successfully extinguished. In the early phase of extinction, we found a significant activation of the caudate, the hippocampus, the dorsal and ventral anterior cingulate cortex (dACC and vACC). In the late phase, we found significant activation of the nucleus accumbens (NAcc) and the amygdala. Correlational analyses with subjective ratings linked extinction success to the vACC and the NAcc, while associating the dACC with reduced extinction. The results reveal neural correlates of appetitive extinction in humans and extend assumptions from models for human extinction learning.
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