ArticleOccupational and environmental medicine2017
Occupational exposure to chlorinated solvents and kidney cancer: a case-control study.
Article in Occupational and environmental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Risk factors for kidney cancer and socio-occupational category: significant impact of chlorinated solvents (UroCCR 111).World journal of urology · 2024Article
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations.Environmental health perspectives · 2023Article
- Evaluation of the updated SOCcer v2 algorithm for coding free-text job descriptions in three epidemiologic studies.Annals of work exposures and health · 2023Article
- Assessment of Occupational Carcinogenic Risk by Comparing Data from the Italian Register of Occupational Exposures to Carcinogens (SIREP) with the International Agency for Research on Cancer (IARC) Evidence.International journal of environmental research and public health · 2023Article
- Differences in risk factors for molecular subtypes of clear cell renal cell carcinoma.International journal of cancer · 2021Article
- Biological monitoring of occupational exposure to dichloromethane by means of urinalysis for un-metabolized dichloromethane.Industrial health · 2020Article
- The long-term rapid increase in incidence of adenocarcinoma of the kidney in the USA, especially among younger ages.International journal of epidemiology · 2019Article
- Using Decision Rules to Assess Occupational Exposure in Population-Based Studies.Current environmental health reports · 2019Review
- Extended Mortality Follow-up of a Cohort of Dry Cleaners.Epidemiology (Cambridge, Mass.) · 2019Article
- Decision rule approach applied to estimate occupational lead exposure in a case-control study of kidney cancer.American journal of industrial medicine · 2018Article
- Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin's lymphoma.Occupational and environmental medicine · 2018Article
- Assessment of the Endocrine-Disrupting Effects of Trichloroethylene and Its Metabolites Using in Vitro and in Silico Approaches.Environmental science & technology · 2018Article
- New Opportunities in Exposure Assessment of Occupational Epidemiology: Use of Measurements to Aid Exposure Reconstruction in Population-Based Studies.Current environmental health reports · 2017Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesTrichloroethylene, a chlorinated solvent widely used for metal degreasing, is classified by the International Agency for Research on Cancer as a kidney carcinogen. Other chlorinated solvents are suspected carcinogens, most notably the cleaning solvent perchloroethylene, although it is unclear whether they are associated with kidney cancer. We investigated kidney cancer associations with occupational exposure to 6 chlorinated solvents (trichloroethylene, perchloroethylene, 1,1,1-trichloroethane, carbon tetrachloride, chloroform, and methylene chloride) within a case-control study using detailed exposure assessment methods.
methodsCases (n=1217) and controls (n=1235) provided information on their occupational histories and, for selected occupations, on tasks involving potential exposure to chlorinated solvents through job-specific interview modules. Using this information, an industrial hygienist assessed potential exposure to each solvent. We computed ORs and 95% CIs for different exposure metrics, with unexposed participants as the referent group.
results1,1,1-trichloroethane, carbon tetrachloride, chloroform, and methylene chloride were not associated with kidney cancer. Among jobs with high exposure intensity, high cumulative hours exposed to perchloroethylene was associated with increased risk, both overall (third tertile vs unexposed: OR 3.1, 95% CI 1.3 to 7.4) and after excluding participants with ≥50% exposure probability for trichloroethylene (OR 3.0, 95% CI 0.99 to 9.0). A non-significant association with high cumulative hours exposed to trichloroethylene was observed (OR 1.7, 95% CI 0.8 to 3.8).
conclusionsIn this study, high exposure to perchloroethylene was associated with kidney cancer, independent of trichloroethylene. Additional studies are needed to further investigate this finding.
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