Evidence map›Paper›PMID 27803036›Full record

Trial reportCirculation2016

Comparative Prognostic Utility of Indexes of Microvascular Function Alone or in Combination in Patients With an Acute ST-Segment-Elevation Myocardial Infarction.

David Carrick, Caroline Haig, Nadeem Ahmed, Jaclyn Carberry, Vannesa Teng Yue May, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Mitchell Lindsay, Stuart Hood and 8 more

2 registry-linked trialsOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 101 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 3 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02072850 active not recruitingnot on this map

Cardiac Magnetic Resonance Imaging: New Pathological Insights and Their Functional and Clinical Significance in ST Elevation Acute Myocardial Infarction.

TypeobservationalSponsorNHS National Waiting Times Centre BoardRan2011 to 2031Enrolled324ConditionsAcute ST-elevation Myocardial InfarctionArmsCoronary pressure wire, Magnetic resonance imaging of the heart
NCT06662890 narecruitingnot on this mapstarted 2024, after this paper: background citation

Supersaturated Oxygen Therapy Using Radial Artery Access to Prevent Left Ventricular Remodeling After Anterior ST-segment Elevation Myocardial Infarction: a Randomized, Controlled Trial

TypeinterventionalSponsorNHS National Waiting Times Centre BoardRan2024 to 2038Enrolled56ConditionsMyocardial Infarct, Remodeling, Left VentricleArmsSupersaturated oxygen, Sham (No Treatment)
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 180 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: part I - analytical validation and clinical qualification.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018
    Guideline
  4. Trial
  5. Trial
  6. Thermodilution-derived temperature recovery time: a novel predictor of microvascular reperfusion and prognosis after myocardial infarction.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021
    Trial
  7. Trial
  8. Interaction between coronary lesion complexity and coronary microvascular dysfunction in the prognosis of NSTEMI patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  9. Review
  10. Unveiling the Microvasculature: The Index of Microcirculatory Resistance and Its Expanding Role in Cardiovascular Care.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Increased Thrombogenicity is Associated With Coronary Microvascular Dysfunction in Patients With STEMI-A Proof-of-Concept Study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

David CarrickFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Caroline HaigFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Nadeem AhmedFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Jaclyn CarberryFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Vannesa Teng Yue MayFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Margaret McEntegartFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Mark C PetrieFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Hany EteibaFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Mitchell LindsayFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Stuart HoodFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Stuart WatkinsFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Andrew DavieFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Ahmed MahrousFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Ify MordiFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Ian FordFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Aleksandra RadjenovicFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Keith G OldroydFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.).
Colin BerryFrom BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., I.M., A.R., K.G.O., C.B.), and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Glasgow, UK; and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK (D.C., N.A., J.C., V.T.Y.M., M.M., M.C.P., H.E., M.L., S.H.., S.W., A.D., A.M., I.M., K.G.O., C.B.). colin.berry@glasgow.ac.uk.
University of Glasgow · GB

Funding

British Heart Foundation FS/12/62/29889British Heart Foundation PG/11/2/28474Medical Research Council MR/N003403/1
6 · The paper itself

Abstract

backgroundPrimary percutaneous coronary intervention is frequently successful at restoring coronary artery blood flow in patients with acute ST-segment-elevation myocardial infarction; however, failed myocardial reperfusion commonly passes undetected in up to half of these patients. The index of microvascular resistance (IMR) is a novel invasive measure of coronary microvascular function. We aimed to investigate the pathological and prognostic significance of an IMR>40, alone or in combination with a coronary flow reserve (CFR≤2.0), in the culprit artery after emergency percutaneous coronary intervention for acute ST-segment-elevation myocardial infarction.

methodsPatients with acute ST-segment-elevation myocardial infarction were prospectively enrolled during emergency percutaneous coronary intervention and categorized according to IMR (≤40 or >40) and CFR (≤2.0 or >2.0). Cardiac magnetic resonance imaging was acquired 2 days and 6 months after myocardial infarction. All-cause death or first heart failure hospitalization was a prespecified outcome (median follow-up, 845 days).

resultsIMR and CFR were measured in the culprit artery at the end of percutaneous coronary intervention in 283 patients with ST-segment-elevation myocardial infarction (mean±SD age, 60±12 years; 73% male). The median IMR and CFR were 25 (interquartile range, 15-48) and 1.6 (interquartile range, 1.1-2.1), respectively. An IMR>40 was a multivariable associate of myocardial hemorrhage (odds ratio, 2.10; 95% confidence interval, 1.03-4.27; P=0.042). An IMR>40 was closely associated with microvascular obstruction. Symptom-to-reperfusion time, TIMI (Thrombolysis in Myocardial Infarction) blush grade, and no (≤30%) ST-segment resolution were not associated with these pathologies. An IMR>40 was a multivariable associate of the changes in left ventricular ejection fraction (coefficient, -2.12; 95% confidence interval, -4.02 to -0.23; P=0.028) and left ventricular end-diastolic volume (coefficient, 7.85; 95% confidence interval, 0.41-15.29; P=0.039) at 6 months independently of infarct size. An IMR>40 (odds ratio, 4.36; 95% confidence interval, 2.10-9.06; P<0.001) was a multivariable associate of all-cause death or heart failure. Compared with an IMR>40, the combination of IMR>40 and CFR≤2.0 did not have incremental prognostic value.

conclusionsAn IMR>40 is a multivariable associate of left ventricular and clinical outcomes after ST-segment-elevation myocardial infarction independently of the infarction size. Compared with standard clinical measures of the efficacy of myocardial reperfusion, including the ischemic time, ST-segment elevation, angiographic blush grade, and CFR, IMR has superior clinical value for risk stratification and may be considered a reference test for failed myocardial reperfusion. CLINICAL

trial registrationURL: https//www.clinicaltrials.gov. Unique identifier: NCT02072850.

Indexed as

Acute DiseaseAgedCohort StudiesCoronary AngiographyCoronary VesselsElectrocardiographyFemaleHemorrhageHumansLogistic ModelsMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionOdds Ratiomagnetic resonance imagingmicrocirculationmyocardial infarctionprognosis

Identifiers

PMID27803036
PMCPMC5131697
OpenAlexW2547076092

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.