ArticleDiabetes2017
Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution.
Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An integrated single cell and spatial transcriptomic map of human white adipose tissue.Nature communications · 2023Pooled it
- Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue.Cell metabolism · 2026Article
- Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders.Cell genomics · 2025Review
- Targeting adipocyte differentiation with CRT0066101: activation of AMPK signaling in 3T3-L1 cells.Frontiers in pharmacology · 2025Article
- IL-1β promotes adipogenesis by directly targeting adipocyte precursors.Nature communications · 2024Article
- A spatiotemporal proteomic map of human adipogenesis.Nature metabolism · 2024Article
- Transcriptional determinants of lipid mobilization in human adipocytes.Science advances · 2024Article
- Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq.Molecular metabolism · 2023Article
- The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase.Nature communications · 2022Article
- Impaired phosphocreatine metabolism in white adipocytes promotes inflammation.Nature metabolism · 2022Article
- Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease.eLife · 2021Article
- LMO3 reprograms visceral adipocyte metabolism during obesity.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health.Cell & bioscience · 2021Review
- Effects of Ginsenoside Rg3 on Inhibiting Differentiation, Adipogenesis, and ER Stress-Mediated Cell Death in Brown Adipocytes.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Molecular mechanisms of fat deposition:Archives animal breeding · 2021Article
- Scopolin Prevents Adipocyte Differentiation in 3T3-L1 Preadipocytes and Weight Gain in an Ovariectomy-Induced Obese Mouse Model.International journal of molecular sciences · 2020Article
- The Targeted Impact of Flavones on Obesity-Induced Inflammation and the Potential Synergistic Role in Cancer and the Gut Microbiota.Molecules (Basel, Switzerland) · 2020Review
- Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation.iScience · 2019Article
- MicroRNA-27a/b-3p and PPARG regulate SCAMP3 through a feed-forward loop during adipogenesis.Scientific reports · 2019Article
- Blubber transcriptome responses to repeated ACTH administration in a marine mammal.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
White adipose tissue (WAT) can develop into several phenotypes with different pathophysiological impact on type 2 diabetes. To better understand the adipogenic process, the transcriptional events that occur during in vitro differentiation of human adipocytes were investigated and the findings linked to WAT phenotypes. Single-molecule transcriptional profiling provided a detailed map of the expressional changes of genes, enhancers, and long noncoding RNAs, where different types of transcripts share common dynamics during differentiation. Common signatures include early downregulated, transient, and late induced transcripts, all of which are linked to distinct developmental processes during adipogenesis. Enhancers expressed during adipogenesis overlap significantly with genetic variants associated with WAT distribution. Transiently expressed and late induced genes are associated with hypertrophic WAT (few but large fat cells), a phenotype closely linked to insulin resistance and type 2 diabetes. Transcription factors that are expressed early or transiently affect differentiation and adipocyte function and are controlled by several well-known upstream regulators such as glucocorticosteroids, insulin, cAMP, and thyroid hormones. Taken together, our results suggest a complex but highly coordinated regulation of adipogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.