Evidence map›Paper›PMID 27802846›Full record

ArticleJournal of the International AIDS Society2016

Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand.

Donn J Colby, Trevor A Crowell, Sunee Sirivichayakul, Suteeraporn Pinyakorn, Eugene Kroon, Khunthalee Benjapornpong, Jintana Intasan, Rapee Trichavaroj, Sodsai Tovanabutra, Merlin Robb and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of the International AIDS Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Acquisition of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Infection in a Patient Taking Preexposure Prophylaxis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Donn J ColbySEARCH-Thailand, Bangkok, Thailand.
Trevor A CrowellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Sunee SirivichayakulThe Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Suteeraporn PinyakornU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Eugene KroonSEARCH-Thailand, Bangkok, Thailand.
Khunthalee BenjapornpongSEARCH-Thailand, Bangkok, Thailand.
Jintana IntasanSEARCH-Thailand, Bangkok, Thailand.
Rapee TrichavarojDepartment of Retrovirology, Armed Forces Research Institute of Medical Sciences - US Component, Bangkok, Thailand.
Sodsai TovanabutraHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Merlin RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Praphan PhanuphakThe Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Jintanat AnanworanichSEARCH-Thailand, Bangkok, Thailand.
Nittaya PhanuphakSEARCH-Thailand, Bangkok, Thailand.
Search 010/RV 254 Study Group
Thai Red Cross Society · THHenry M. Jackson Foundation · USWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAs availability of antiretroviral therapy expands in developing countries, the risk for transmission of drug-resistant HIV also increases. Patients with acute HIV infection (AHI) provide an opportunity for real-time monitoring of transmitted drug resistance (TDR). SEARCH 010/RV 254 study is a prospective, longitudinal study of AHI. This analysis was performed to characterize changes in TDR over time in persons enrolled in the AHI cohort.

methodsGenotype testing for TDR mutations was performed on 229 subjects enrolled from 2009 to 2014.

resultsThe cohort was predominantly male (95%) and men who have sex with men (92%). TDR prevalence was 7.0%, declining from 12.5% in 2009-2010 to 4.8% in 2013-2014 (

conclusionsTDR appears to be declining among individuals with AHI in Bangkok and in 2013 to 2014 met the World Health Organization definition for low prevalence. Continued surveillance is necessary to determine if this trend persists.

Indexed as

AdultAnti-HIV AgentsCohort StudiesDrug Resistance, ViralFemaleGenotypeHIV-1HIV InfectionsHomosexuality, MaleHumansLongitudinal StudiesMaleMiddle AgedMutationPrevalenceProspective StudiesAnti-HIV Agentsacute HIV infectionmen who have sex with menThailandtransmitted drug resistance

Identifiers

PMID27802846
PMCPMC5090107
OpenAlexW2540738668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.