ArticleGenome biology2016
Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly.
Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 146 citations in OpenAlex.
- Feeding biomechanics in vertebrates and beyond.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Over-Representation of Sperm-Associated Deleterious Mutations Across Wild and Ex Situ Cheetah (Acinonyx jubatus) Populations.Molecular ecology · 2026Article
- First Genome Assembly of the Critically Endangered Arabian Leopard (International journal of molecular sciences · 2026Article
- Comparative analysis of morphology and gut microbiome underlying trophic niche differentiation in three stomatopod species.BMC microbiology · 2026Article
- Genomic Insights Into Carnivorous Fish in the Characiformes.Ecology and evolution · 2026Article
- Genomic divergence of leopards in the Cape Floristic Region of South Africa: potential drivers for local adaptation.Heredity · 2026Article
- Dietary drivers of gut microbiota diversity and function in wildlife of Wolong Nature Reserve: a metagenomic study.Current zoology · 2026Article
- Exceedingly low genetic diversity in snow leopards due to persistently small population size.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Human Digestive Physiology and Evolutionary Diet: A Metabolomic Perspective on Carnivorous and Scavenger Adaptations.Metabolites · 2025Review
- Hybrid genome assembly of the widespread bat Rhinolophus lepidus provides insights into susceptibility to SARS-CoV-2 infection and climate change threat.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- Parameterizing Pantherinae: De Novo Mutation Rate Estimates from Panthera and Neofelis Pedigrees.Genome biology and evolution · 2025Article
- The relationship between diet, plasma glucose, and cancer prevalence across vertebrates.Nature communications · 2025Article
- Population Genetic Diversity and Viability of the North China Leopard (Ecology and evolution · 2025Article
- Molecular evolution of dietary shifts in ladybird beetles (Coleoptera: Coccinellidae): from fungivory to carnivory and herbivory.BMC biology · 2025Article
- Convergent Evolution and Predictability of Gene Copy Numbers Associated with Diets in Mammals.Genome biology and evolution · 2025Article
- Inferring the historical demography of southern African cheetahs (Acinonyx jubatus) using Bayesian analyses of molecular genetic data.Genetics and molecular biology · 2025Article
- Convergent relaxation of molecular constraint in herbivores reveals the changing role of liver and kidney functions across mammalian diets.Genome research · 2024Article
- Article
- RERconverge Expansion: Using Relative Evolutionary Rates to Study Complex Categorical Trait Evolution.Molecular biology and evolution · 2024Article
- The Chinese longsnout catfish genome provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores.Genome research · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 18 institutions in 4 countries.
Funding
Abstract
backgroundThere are three main dietary groups in mammals: carnivores, omnivores, and herbivores. Currently, there is limited comparative genomics insight into the evolution of dietary specializations in mammals. Due to recent advances in sequencing technologies, we were able to perform in-depth whole genome analyses of representatives of these three dietary groups.
resultsWe investigated the evolution of carnivory by comparing 18 representative genomes from across Mammalia with carnivorous, omnivorous, and herbivorous dietary specializations, focusing on Felidae (domestic cat, tiger, lion, cheetah, and leopard), Hominidae, and Bovidae genomes. We generated a new high-quality leopard genome assembly, as well as two wild Amur leopard whole genomes. In addition to a clear contraction in gene families for starch and sucrose metabolism, the carnivore genomes showed evidence of shared evolutionary adaptations in genes associated with diet, muscle strength, agility, and other traits responsible for successful hunting and meat consumption. Additionally, an analysis of highly conserved regions at the family level revealed molecular signatures of dietary adaptation in each of Felidae, Hominidae, and Bovidae. However, unlike carnivores, omnivores and herbivores showed fewer shared adaptive signatures, indicating that carnivores are under strong selective pressure related to diet. Finally, felids showed recent reductions in genetic diversity associated with decreased population sizes, which may be due to the inflexible nature of their strict diet, highlighting their vulnerability and critical conservation status.
conclusionsOur study provides a large-scale family level comparative genomic analysis to address genomic changes associated with dietary specialization. Our genomic analyses also provide useful resources for diet-related genetic and health research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.