Evidence map›Paper›PMID 27802830›Full record

ReviewMicrobiome2016

The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?

Anita Mitra, David A MacIntyre, Julian R Marchesi, Yun S Lee, Phillip R Bennett, Maria Kyrgiou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microbiome, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed, 13 pooled it
17.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

282 citing papers in PubMed, 13 syntheses or guidelines pooled it, 485 citations in OpenAlex.

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222 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Anita MitraInstitute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Department of Surgery and Cancer, Imperial College London, Du Cane Road, W120NN, London, UK.
David A MacIntyreInstitute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Department of Surgery and Cancer, Imperial College London, Du Cane Road, W120NN, London, UK. d.macintyre@imperial.ac.uk.
Julian R MarchesiSchool of Biosciences, Cardiff University, Cardiff, UK.
Yun S LeeInstitute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Department of Surgery and Cancer, Imperial College London, Du Cane Road, W120NN, London, UK.
Phillip R BennettInstitute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Department of Surgery and Cancer, Imperial College London, Du Cane Road, W120NN, London, UK.
Maria KyrgiouInstitute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Department of Surgery and Cancer, Imperial College London, Du Cane Road, W120NN, London, UK. m.kyrgiou@imperial.ac.uk.
Imperial College London · GBCardiff University · GBHammersmith Hospital · GBImperial College Healthcare NHS Trust · GB

Funding

Medical Research Council MR/L009226/1Medical Research Council P47569
6 · The paper itself

Abstract

The vaginal microbiota plays a significant role in health and disease of the female reproductive tract. Next-generation sequencing techniques based upon the analysis of bacterial 16S rRNA genes permit in-depth study of vaginal microbial community structure to a level of detail not possible with standard culture-based microbiological techniques. The human papillomavirus (HPV) causes both cervical intraepithelial neoplasia (CIN) and cervical cancer. Although the virus is highly prevalent, only a small number of women have a persistent HPV infection and subsequently develop clinically significant disease. There is emerging evidence which leads us to conclude that increased diversity of vaginal microbiota combined with reduced relative abundance of Lactobacillus spp. is involved in HPV acquisition and persistence and the development of cervical precancer and cancer. In this review, we summarise the current literature and discuss potential mechanisms for the involvement of vaginal microbiota in the evolution of CIN and cervical cancer. The concept of manipulation of vaginal bacterial communities using pre- and probiotics is also discussed as an exciting prospect for the field of cervical pathology.

Indexed as

MicrobiotaDysbiosisFemaleHumansLactobacillusOxidative StressPapillomaviridaePapillomavirus InfectionsProbioticsRNA, Ribosomal, 16SUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginaRNA, Ribosomal, 16SCervical cancerCervical intraepithelial neoplasiaCINHPVHuman papillomavirusLactobacillus speciesPrebioticsProbioticsVaginal microbiota

Identifiers

PMID27802830
PMCPMC5088670
OpenAlexW2546959673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.