ReviewJournal of neurogenetics
Ion channels as insecticide targets.
Review in Journal of neurogenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 109 citations in OpenAlex.
- Sex-specific responses to repeated dose of abamectin in albino rats: a focus on cytotoxicity, genotoxicity, and pro-inflammatory signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Design, synthesis, and insecticidal potency of novel 3-methyl-pyrazole derivatives against Culex pipiens larvae.Scientific reports · 2026Article
- Knockdown effects of pyrethroid- and neonicotinoid-treated netting against the sand fly Phlebotomus papatasi (Diptera: Psychodidae).Parasites & vectors · 2026Article
- Intracellular calcium handling dysfunction contributes to behavioural deficits leading to mortality of honey bees after acute contact exposure to the insecticide cyantraniliprole.Scientific reports · 2026Article
- No ancillary proteins are essential for the functional heterologous expression of the homomeric α6 nicotinic acetylcholine receptor from the brown castor tickCurrent research in parasitology & vector-borne diseases · 2026Article
- Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.Parasites & vectors · 2025Review
- Molecular detection of novel Glutamate-gated chloride channel mutations in field collected human head lice (Phthiraptera: Pediculidae) from Iran.BMC research notes · 2025Article
- The flavonoid rutin protects against imidacloprid-induced osmotic and electric disruptions in Africanized honey bees.PloS one · 2025Article
- Upregulation of ACSL, ND75, Vha26 and sesB genes by antiepileptic drugs resulted in genotoxicity in drosophila.Toxicology research · 2024Article
- Uncovering the genetic diversity in Aedes aegypti insecticide resistance genes through global comparative genomics.Scientific reports · 2024Article
- Insecticide resistance reduces the profitability of insect-resistant rice cultivars.Journal of advanced research · 2024Article
- Article
- G3'MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner.PLoS genetics · 2023Article
- Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) inToxicology reports · 2023Article
- Transposable elements and xenobiotic resistance.Frontiers in insect science · 2023Review
- N-Type Inactivation Variances in Honeybee and Asian Giant Hornet Kv Channels.Bioelectricity · 2022Article
- The effects of dietary proline, β-alanine, and γ-aminobutyric acid (GABA) on the nest construction behavior in the Oriental hornet (Vespa orientalis).Scientific reports · 2022Article
- Article
- A review of physiological resistance to insecticide stress in3 Biotech · 2022Review
- Gene drives gaining speed.Nature reviews. Genetics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ion channels remain the primary target of most of the small molecule insecticides. This review examines how the subunit composition of heterologously expressed receptors determines their insecticide-specific pharmacology and how the pharmacology of expressed receptors differs from those found in the insect nervous system. We find that the insecticide-specific pharmacology of some receptors, like that containing subunits of the Rdl encoded GABA receptor, can be reconstituted with very few of the naturally occurring subunits expressed. In contrast, workers have struggled even to express functional insect nicotinic acetylcholine receptors (nAChRs), and work has therefore often relied upon the expression of vertebrate receptor subunits in their place. We also examine the extent to which insecticide-resistance-associated mutations, such as those in the para encoded voltage-gated sodium channel, can reveal details of insecticide-binding sites and mode of action. In particular, we examine whether mutations are present in the insecticide-binding site and/or at sites that allosterically affect the drug preferred conformation of the receptor. We also discuss the ryanodine receptor as a target for the recently developed diamides. Finally, we examine the lethality of the genes encoding these receptor subunits and discuss how this might determine the degree of conservation of the resistance-associated mutations found.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.