Evidence map›Paper›PMID 27802529›Full record

ArticleJAMA2016

Confounding by Indication in Clinical Research.

Demetrios N Kyriacou, Roger J Lewis

Registry-linked trialAbstract readComment
PubMed Publisher
In one paragraph

Article in JAMA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06666647 (Ambulance and Helicopter Response Times in Danish Emergency Medical Services), which is not on this map. Cited by 295 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
295citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06666647 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Ambulance and Helicopter Response Times in Danish Emergency Medical Services: Protocol for an Epidemiological Study. The AHRTEMIS Study

TypeobservationalSponsorPeter Martin HansenRan2025 to 2026Enrolled2,500,000ConditionsEmergency Medical Services, Response, Triage, Survival OutcomesArmsTreatment by ambulance or helicopter services with response times
3 · Its place in the literature

Who cites it

295 citing papers in PubMed, 24 syntheses or guidelines pooled it.

  1. Pooled it
  2. Minimizing blood sampling in preterm infants.The Cochrane database of systematic reviews · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Decongestants and antihistamines for acute otitis media in children.The Cochrane database of systematic reviews · 2025
    Pooled it
  7. Indications and timings for caffeine initiation in preterm infants.The Cochrane database of systematic reviews · 2025
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Acupuncture for procedural pain in newborn infants.The Cochrane database of systematic reviews · 2025
    Pooled it
  13. Pooled it
  14. Acupuncture for neonatal abstinence syndrome in newborn infants.The Cochrane database of systematic reviews · 2025
    Pooled it
  15. Pooled it
  16. Acupuncture for hypoxic ischemic encephalopathy in neonates.The Cochrane database of systematic reviews · 2024
    Pooled it
  17. Strategies for cessation of caffeine administration in preterm infants.The Cochrane database of systematic reviews · 2024
    Pooled it
  18. Pooled it
  19. Pooled it
  20. Superoxide dismutase for bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2023
    Pooled it

235 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Demetrios N KyriacouDepartments of Emergency Medicine and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois2Senior Editor, JAMA.
Roger J LewisDepartment of Emergency Medicine, Harbor-UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiasConfounding Factors, EpidemiologicBiomedical ResearchHumansResearch Design

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.