ArticleDementia and geriatric cognitive disorders2016
Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.
Article in Dementia and geriatric cognitive disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.Antioxidants (Basel, Switzerland) · 2026Article
- Joint associations of handgrip strength and functional disability with cognitive impairment in older adults.European journal of medical research · 2025Article
- Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy.AIDS research and therapy · 2024Article
- Mediation Effect of Oxidative Stress on Association Between Selenium Intake and Cognition in American Adults.Nutrients · 2024Article
- Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and Subsequent Analyses.Antioxidants (Basel, Switzerland) · 2024Article
- Association between Handgrip Strength and Cognitive Function in Older Adults: Korean Longitudinal Study of Aging (2006-2018).International journal of environmental research and public health · 2022Article
- Association between change in handgrip strength and cognitive function in Korean adults: a longitudinal panel study.BMC geriatrics · 2021Article
- Evaluation of oxidative stress and antioxidant capacity in healthy children.Journal of the Chinese Medical Association : JCMA · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
BACKGROUND/
aimsOxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age.
methodsSubjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores cross-sectionally (n = 4,304) and prospectively (n = 2,882).
resultsIncreased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function.
conclusionThis study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.
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