Evidence map›Paper›PMID 27802416›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

Src Kinases Regulate Glutamatergic Input to Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension.

Xin Qiao, Jing-Jing Zhou, De-Pei Li, Hui-Lin Pan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Calcineurin regulates synaptic CaThe Journal of physiology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. α2δ-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xin QiaoFrom the Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine (X.Q., H.-L.P.), and Department of Critical Care (J.-J.Z., D.-P.L.), The University of Texas MD Anderson Cancer Center, Houston.
Jing-Jing ZhouFrom the Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine (X.Q., H.-L.P.), and Department of Critical Care (J.-J.Z., D.-P.L.), The University of Texas MD Anderson Cancer Center, Houston.
De-Pei LiFrom the Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine (X.Q., H.-L.P.), and Department of Critical Care (J.-J.Z., D.-P.L.), The University of Texas MD Anderson Cancer Center, Houston.
Hui-Lin PanFrom the Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine (X.Q., H.-L.P.), and Department of Critical Care (J.-J.Z., D.-P.L.), The University of Texas MD Anderson Cancer Center, Houston. huilinpan@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Signaling Mechanisms of CNS Neuronal Plasticity in HypertensionR01HL131161 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, HUI-LIN · 2016 to 2019
$2.1M
Hypothalamic Neuronal Plasticity in Chronic StressR01MH096086 · NIMH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, DE-PEI · 2013 to 2017
$1.8M
NHLBI NIH HHS R01 HL131161NIMH NIH HHS R01 MH096086
6 · The paper itself

Abstract

The elevated sympathetic outflow associated with hypertension is maintained by increased N-methyl-d-aspartate receptor (NMDAR) activity in the paraventricular nucleus (PVN) of the hypothalamus. Synaptic NMDAR activity is tightly regulated by protein kinases, including the Src family of tyrosine kinases. We determined whether Src kinases play a role in increased NMDAR activity of PVN neurons projecting to the rostral ventrolateral medulla and in elevated sympathetic vasomotor tone in spontaneously hypertensive rats (SHRs). The Src protein level in the PVN was significantly greater in SHRs than in normotensive Wistar-Kyoto (WKY) rats and was not significantly altered by lowering blood pressure with celiac ganglionectomy in SHRs. Inhibition of Src kinase activity with 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2) completely normalized the higher amplitudes of evoked NMDAR-mediated excitatory postsynaptic currents and puff NMDA-elicited currents of rostral ventrolateral medulla-projecting PVN neurons in SHRs. PP2 treatment also attenuated the higher frequency of NMDAR-mediated miniature excitatory postsynaptic currents of these neurons in SHRs. However, PP2 had no effect on NMDAR-excitatory postsynaptic currents or miniature excitatory postsynaptic currents of rostral ventrolateral medulla-projecting PVN neurons in WKY rats. NMDAR activity increased by an Src-activating peptide was blocked by PP2 but not by inhibition of casein kinase 2. In addition, microinjection of PP2 into the PVN not only decreased lumbar sympathetic nerve discharges and blood pressure but also eliminated the inhibitory effect of the NMDAR antagonist on sympathetic nerve activity and blood pressure in SHRs. Collectively, our findings suggest that increased Src kinase activity potentiates presynaptic and postsynaptic NMDAR activity in the PVN and sympathetic vasomotor tone in hypertension.

Indexed as

AnimalsBlood PressureBlotting, WesternDisease Models, AnimalExcitatory Postsynaptic PotentialsHypertensionHypothalamusMaleNeuronsRatsRats, Inbred SHRRats, Inbred WKYReceptors, N-Methyl-D-Aspartatesrc-Family KinasesSympathetic Nervous SystemReceptors, N-Methyl-D-Aspartatesrc-Family Kinasesautonomic nervous systemhypertensionhypothalamusNMDA receptorsympathetic nerve dischargessynaptic plasticity

Identifiers

PMID27802416
PMCPMC5145744
OpenAlexW2542590893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.