ArticlePloS one2016
Non-Enzymatic Oligomerization of 3', 5' Cyclic AMP.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Concurrent Phosphite Oxidation and Adenosine Phosphorylation Under Prebiotic Evaporative Conditions.Journal of molecular evolution · 2026Article
- Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry.Nature communications · 2025Article
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Microfluidics-Based Drying-Wetting Cycles to Investigate Phase Transitions of Small Molecules Solutions.Life (Basel, Switzerland) · 2024Article
- Catalytic Synthesis of Polyribonucleic Acid on Prebiotic Rock Glasses.Astrobiology · 2022Article
- Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Questions and Answers Related to the Prebiotic Production of Oligonucleotide Sequences from 3',5' Cyclic Nucleotide Precursors.Life (Basel, Switzerland) · 2021Review
- Geochemical influences on nonenzymatic oligomerization of prebiotically relevant cyclic nucleotides.RNA (New York, N.Y.) · 2020Article
- The torpedo effect in Bacillus subtilis: RNase J1 resolves stalled transcription complexes.The EMBO journal · 2020Article
- Chemomimesis and Molecular Darwinism in Action: From Abiotic Generation of Nucleobases to Nucleosides and RNA.Life (Basel, Switzerland) · 2018Review
- Rewarming the Primordial Soup: Revisitations and Rediscoveries in Prebiotic Chemistry.Chembiochem : a European journal of chemical biology · 2018Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies illustrate that short oligonucleotide sequences can be easily produced from nucleotide precursors in a template-free non-enzymatic way under dehydrating conditions, i.e. using essentially dry materials. Here we report that 3',5' cyclic AMP may also serve as a substrate of the reaction, which proceeds under moderate conditions yet with a lower efficiency than the previously reported oligomerization of 3',5' cyclic GMP. Optimally the oligomerization requires (i) a temperature of 80°C, (ii) a neutral to alkaline environment and (iii) a time on the order of weeks. Differences in the yield and required reaction conditions of the oligomerizations utilizing 3',5' cGMP and cAMP are discussed in terms of the crystal structures of the compounds. Polymerization of 3',5' cyclic nucleotides, whose paramount relevance in a prebiotic chemistry context has been widely accepted for decades, supports the possibility that the origin of extant genetic materials might have followed a direct uninterrupted path since its very beginning, starting from non-elaborately pre-activated monomer compounds and simple reactions.
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